来氟米特与甲氨蝶呤治疗类风湿关节炎的疗效及安全性分析

Efficacy and Safety of the Treatment of Rheumatoid Arthritis with Methotr exate and Methotrexate

目的研究来氟米特与甲氨蝶呤治疗类风湿关节炎的疗效及安全性。方法该次研究方便选取的研究对象为2014年2月—2016年2月期间在该院进行治疗的类风湿关节炎90例患者,采用简单随机分为2组,45例为一组。甲氨蝶呤治疗(对照组),来氟米特治疗(观察组)。对比两组类风湿关节炎患者的临床总有效率、临床症状改善情况、血清学指标以及不良反应发生率。结果观察组类风湿关节炎患者的临床总有效率(97.78%)、临床症状改善情况[晨僵时间(12.76±5.32)min、关节压痛数(2.08±0.48)个和关节肿胀数(1.14±0.39)个]、血清学指标[血细胞沉降率(20.54±3.82)mm/h、C反应蛋白(21.66±3.75)mg/L、白细胞介素(5.38±1.00)pg/m L、IL-6(6.78±1.23)pg/m L和肿瘤坏死因子(7.14±1.29)pg/m L]以及不良反应发生率(6.67%)均优于对照组患者(P<0.05)。结论在治疗类风湿关节炎患者时应用来氟米特的疗效和安全性优于甲氨蝶呤,明显改善了患者的临床症状。

Objective Research to fluorine, and methotrexate therapy efficacy and safety of rheumatoid arthritis.Methods Convenient selection the research object of this study selected for February 2014 to February 2016 treated in our hospital during the period of patients with rheumatoid arthritis.The simple 90 patients were randomly divided into 2 groups, 45 cases as a group. Methotrexate therapy（control group） to fluorine milt treatment（observation group）. Compared two groups of patients with rheumatoid arthritis the clinical total effective rate, clinical symptoms improved, serological index and incidence of adverse reactions. Results The total efficiency（97.78%）in patients with rheumatoid arthritis clinical observation and clinical symptoms improved [the time of morning stiffness（12.76±5.32）minutes,tender joint count（2.08±0.48）and swollen joint count（1.14±0.39）],serological indexes,[blood cells sedimentation rate（20.54±3.82）mm/h,C reactive protein（21.66±3.75）mg/L,leukocyte mediated hormone（5.38±1.00）pg/m L, IL-6（6.78±1.23）pg/m L and tumor necrosis factor（7.14±1.29）gp/m L] and adverse reactions occur rate（6.67%）were better than those of the control group（P〈0.05）. Conclusion In the treatment of rheumatoid arthritis patients when applied to fluorine, the curative effect and safety of superior to methotrexate, significantly improve the clinical symptoms of patients.