左卡尼汀治疗不稳定型心绞痛患者疗效观察

Therapeutic effect of L-carnitine on patients with unstable angina pectoris

目的:观察左卡尼汀治疗不稳定型心绞痛(UAP)患者的疗效及安全性。方法:124例UAP患者采用随机数字法均分为常规治疗组和左卡尼汀组(在常规治疗组基础上加用左卡尼汀注射液2.0g静脉滴注,每日1次),两组均治疗1周。观察比较两组治疗前后的心绞痛发作次数、发作持续时间及心电图改善情况。结果:与治疗前比较,两组治疗后心绞痛发作次数、发作持续时间、ST段压低≥0.05mV的导联数(NST)和12导联中ST段压低幅度总和(∑ST)均显著减少和减小(P<0.05或<0.01);与常规治疗组比较,左卡尼汀组治疗后心绞痛发作次数[(1.58±0.03)次/周比(1.28±0.01)次/周]、发作持续时间[(0.31±0.03)分/周比(0.15±0.03)分/周]、NST[(1.55±0.04)个比(1.04±0.10)个]和∑ST[(0.27±0.02)mV比(0.15±0.01)mV]减少更显著(P<0.05或<0.01)。两组不良反应发生率无显著差异。结论:左卡尼汀对不稳定型心绞痛患者的疗效显著优于常规治疗,且无明显不良反应。

Objective：To observe therapeutic effect and safety of L-carnitine on patients with unstable angina pectoris（UAP）.Methods：According to random number table,a total of 124 UAP patients were randomly and equally divided into routine treatment group and L-carnitine group（received L-carnitine injection 2.0g intravenous drip,once/d based on routine treatment group）,both groups were treated for one week.Onset times and duration of angina pectoris and ECG improvements before and after treatment were observed and compared between two groups.Results：Compared with before treatment,there were significant reductions in onset times and duration of angina pectoris,number of leads in which ST segment depressed≥0.05mV（NST）and sum of ST segment depression extent in 12 leads（∑ST）in both groups after treatment,P〈0.05or0.01;Compared with routine treatment group after treatment,there were significant reductions in onset times[（1.58±0.03）times/week vs.（1.28±0.01）times/week]and duration[（0.31±0.03）min/week vs.（0.15±0.03）min/week]of angina pectoris,NST [（1.55±0.04）vs.（1.04±0.10）]and∑ST [（0.27±0.02）mV vs.（0.15±0.01）mV]in L-carnitine group,P〈0.05or0.01.There was no significant difference in incidence rate of adverse reactions between two groups.Conclusion：L-carnitine possesses more significant therapeutic effect than that of routine treatment on patients with unstable angina pectoris,and there is no obvious adverse reactions.