联合快速心房起搏与快速静脉输液建立犬急性心房颤动模型

Canine model of acute atrial fibrillation established by rapid atrial pacing combined rapid intravenous infusion

目的:研究犬急性心房颤动模型的建立。方法:取24条健康成年杂种犬,随机均分为单纯快速心房起搏组(RAP组)、单纯快速静脉输液组和RAP+快速静脉输液组,尝试建立犬急性房颤模型,比较各组房颤诱发率和房颤持续时间。结果:与RAP组、单纯快速静脉输液组比较,RAP+快速静脉输液组房颤诱发率(0%比0%比62.5%)和房颤平均持续时间[0比0比(115.68±135.87)s]均显著升高,P均<0.01。结论:联合快速心房起搏+快速静脉输液可成功建立心房颤动模型。

Objective：To study establishment of canine acute atrial fibrillation（AF）model.Methods：A total of 24 healthy adult mongrel dogs were selected,randomly and equally divided into pure rapid atrial pacing group（RAP group）,pure rapid intravenous infusion group and RAP ＋ rapid intravenous infusion group,then canine acute AF model was tried to establish in each group using corresponding method.Inducible rate and duration of AF were compared among three groups.Results：Compared with RAP group and pure rapid intravenous infusion group,there were significant rise in inducible rate（0% vs.0% vs.62.5%）and mean duration[0vs.0vs.（115.68±135.87）s]of AF in RAP ＋ rapid intravenous infusion group,P〈0.01 all.Conclusion：Neither pure rapid atrial pacing nor rapid intravenous infusion could induce atrial fibrillation successfully.Combination of both can establish atrial fibrillation model.