三氧化二砷心脏毒性研究进展

Research advances on cardiac toxicity of arsenic trioxide

三氧化二砷(As_2O_3)在临床上治疗急性早幼粒细胞白血病作用明显,且近年来发现对其他恶性肿瘤亦有良好的效果。但随研究不断深入,As_2O_3的心脏毒性报道也逐渐增多,限制了其临床的广泛应用。目前研究认为三氧化二砷诱导的心脏毒性主要与心脏离子通道改变、氧化应激损伤和诱导细胞凋亡有关。该文现就三氧化二砷心脏毒性机制研究及防治进展做一综述。

Arsenic trioxide has a significantly positive effect on the treatment of acute promyelocyte leukemia（ APL）,and it also has been proved that arsenic trioxide can protect against some other kinds of malignant tumors in recent years. However,with the further research about arsenic trioxide,the reports about cardiac toxicity of arsenic trioxide are increasing. Currently,the possible mechanisms of As2O3-induced cardiotoxicity are mainly considered to be associated with changes in cardiac ion channels,oxidative stress injury and apoptosis. Research advances on cardiac toxicity of arsenic trioxide and some ways of prevention are summarized.