摘要
EB病毒属于疱疹病毒γ亚科，为双链DNA病毒。血清流行病学调查显示，EB病毒在人群中的感染率超过95％。EB病毒是最成功的一种病毒，可在宿主记忆B淋巴细胞内建立持续终身的潜伏感染。同时，EB病毒也是第1个被发现的肿瘤病毒，与伯基特淋巴瘤、霍奇金淋巴瘤、鼻咽癌、部分类型的胃癌、T／自然杀伤细胞淋巴瘤等相关。除肿瘤性疾病，EB病毒感染还可引起非恶性淋巴增殖性疾病及自身免疫性疾病等。现主要介绍儿童EB病毒感染相关疾病。
Epstein - Barr virus （EBV） is a gamma herpesvirus with a double -stranded DNA genome. Seroe- pidemiologic surveys indicate that over 95% of adults worldwide are infected with EBV. EBV is one of the successful virus and can result in a lifelong infection in memory B lymphocytes. EBV is the first human candidate tumor virus, and which has been found associated with many more malignant diseases in addition to Burkitt＇s lymphoma, including Hodgkin＇s lymphoma, nasopharyngeal carcinoma , a subset of gastric carcinomas, rare T/natural killer cell lymphomas, and many more. However, not only malignant diseases, but also some autoimmune diseases and the lymphocytosis of infectious mononucleosis have been found to be linked to EBV. In this review, EBV associated diseases in children was focused.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2016年第22期1683-1686,共4页
Chinese Journal of Applied Clinical Pediatrics
关键词
EB病毒
EB病毒相关疾病
儿童
Epstein - Barr virus
Epstein - Barr virus associated diseases
Child
