摘要
Epstein—Barr病毒（EBV）是一种常见的疱疹病毒，人类普遍易感，其感染可致多种不同疾病。存在某些基因缺陷的人群感染EBV后常临床症状重，可引发严重疾病，如噬血细胞综合征、慢性活动性EBV感染及肿瘤等，预后不良。发现潜在的基因缺陷疾病有助于对EBV感染早期防范及治疗。现对EBV感染相关疾病的基因缺陷研究进展进行综述。
Epstein- Ban- virus （EBV） is a common herpes virus, which is generally susceptible for human. EBV infection can also cause various diseases. When individuals with some genes defects or primary immunodeficiency disease who were infected with EBV virus, they may present severe clinical symptoms who have the poor prognosis, such as hemophagocytic lymphohistiocytosis, chronic active EBV infection or tumor. Searching the potential genetic defects is helpful to the prevention and early treatment of EBV infection. Now,the research progress of genes defects in EBV infection related diseases was summarized.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2016年第22期1696-1699,共4页
Chinese Journal of Applied Clinical Pediatrics
关键词
EB病毒
基因缺陷
噬血细胞综合征
免疫缺陷病
Epstein - Barr virus
Genetic defect
Hemophagocytic lymphohistiocytosis
Immunodeficiency disease
