安徽省老年期痴呆危险因素的巢式病例对照研究

Risk factors of senile dementia in Anhui Province: a nested case-control study

目的探讨老年期痴呆相关危险因素,为采取相应干预措施提供依据。方法采用整群抽样的方法,于2008年在安徽省抽取1个城市社区和1个农村乡镇作为研究现场,对2608位年龄≥65岁的老人队列进行基线调查,并在5年后成功随访到944人。采用巢式病例对照研究,将新发80例老年期痴呆患者作为病例组,按照1:3频数匹配,随机抽取240例地区、性别相同,年龄相差不超过5岁且未患痴呆的对象作为对照,采用单因素和多因素Logistic回归分析老年期痴呆的相关危险因素。结果多因素Logistic回归结果显示过去吸烟和被动吸烟可增加老年期痴呆的发病风险。结论过去吸烟和被动吸烟可能是安徽地区老年期痴呆发病的危险因素,应当针对重点人群进行干预,降低老年期痴呆发病风险。

Objective：To investigate the related risk factors of senile dementia（SD）and provide a scientific basis for intervention. Methods：Totally 2608 permanent residents aged 65 and above from a city community and a rural township in Anhui province,which were selected by cluster sampling method,participated in baseline survey in 2008. After 5 years the follow-up was completed in 944 people. A nested case-control study was performed in 80 cases with senile dementia in the same area,with the same gender and the age difference of not more than 5 years old. The related risk factors were screened out with single and multi-factor logistic regression. Results：The multi-factor logistic regression showed that past smoking and passive smoking increased the risk of senile dementia. Conclusion：Senile dementia is related to past smoking and pas-sive smoking in Anhui province. Integrated intervention on high risk group is an important way to reduce the risk of senile dementia of this group.