胃食管反流病患者心理因素与疾病症状的相关性分析

The correlation analysis of the relationship between the psychological factors and symptoms for gastroesophageal reflux disease in patients with gastroesophageal reflux disease

目的探讨胃食管反流病患者心理因素与胃食管反流病症状的相关性。方法选取2014年1月—2014年12月在新汶矿业集团中心医院消化内科,经确诊为反流性食管病患者80例为实验组,并在同期我院查体中心收治健康人群80例为对照组。对所有受试者进行一般情况统计,进行焦虑和抑郁评分。对比两组患者的一般情况及焦虑、抑郁情况。实验组病人根据焦虑、抑郁量表结果,分成具有焦虑的A组患者24例、抑郁的B组患者23例,非焦虑、抑郁的C组患者33例。将A、B、C三组患者心理状况与烧心、反酸、胸痛症状积分进行相关性分析。结果(1)实验组比对照组患有抑郁、焦虑的患者明显增多(χ~2=12.227,P=0.002)。即患GERD增加了患者焦虑、抑郁状态。(2)实验组三组患者胸痛、反酸、烧心等临床症状的方差分析显示:组间比较在烧心、胸痛、反酸方面,有显著差异(P<0.01)。(3)两两比较,抑郁组、焦虑组在烧心、胸痛、反酸等方面比较无差异。抑郁组与正常组,焦虑组与正常组在烧心、胸痛、反酸方面,均有显著差异。(4)抑郁、焦虑与GERD临床症状积分的严重程度相关性分析显示:抑郁与RQC积分呈正相关,y=1.3333x+12.667,R^2=0.7788。焦虑与RQC积分呈正相关,y=0.8594x+19.245,R^2=0.6959。结论 GERD患者比健康人焦虑及抑郁发病率增高。焦虑、抑郁的患者比无焦虑、抑郁的患者,烧心、反酸、胸痛的积分增加,焦虑、抑郁与GERD症状的严重程度呈正相关,即患者焦虑、抑郁越重,GERD的症状越明显。

Objective：To investigate the relationship between the psychological factors and symptoms for gastroesopha-geal reflux disease in patients with gastroesophageal reflux disease. Methods：We selected 80 consecutive cases with reflux esophageal disease admitted between January and December,2014 in the Department of Gastroenterology of XinWen Mining Group Center Hospital. In the same period,80 cases healthy population were in the control group. The general situation, anxiety and depression score were statistics. The experimental group was divided into the group A with anxiety（n = 24）,the group B with depression（n = 23）,and the group C without anxiety or depression（n = 33）,In three group,psychological status indices were analyzed for their correlation with heartburn and regurgitation and chest pain symptom. Results：（1） Compared with the control group,depression and anxiety was significantly increased in the experimental group（ χ2 =12. 227,P = 0. 002）in.（2）In the experimental group,the result of variance analysis revealed that there were significant differences between the groups in terms of heartburn,chest pain,acid reflux（P 0. 05）. （3）Compared to the depression group and normal group,there were significant differences be-tween the anxiety group and the normal group in the chest pain,heartburn,acid reflux（P 〈 0. 05）.（4）The analysis of the correlation between depression,anxiety and the severity of clinical symptom scores of GERD showed that depression was positively correlated with RQC score,R2 = 0. 7788,y = 1. 3333x ＋ 12. 667. Anxiety was positively correlated with RQC score,R2 = 0. 6959,y = 0. 8594x ＋ 19. 245. Conclusion：The incidence of anxiety and depression in GERD patients is higher than that of healthy people,and the more severe anxiety and depression are,the more obvious the symptoms of GERD are.