类风湿因子在原发性干燥综合征不同临床表现中的意义

Significance of rheumatoid factor in different clinical manifestations of primary Sjgren's syndrome

目的：探讨类风湿因子在原发性干燥综合征不同临床表现中的意义。方法：分析98例吉林大学白求恩第一医院2014~2015年原发性干燥综合征患者的临床资料,了解类风湿因子在原发性干燥综合征中的意义。结果：类风湿因子在原发性干燥综合征中的检出率为40.8%,类风湿因子阳性组患者较阴性组患者更易出现乏力、关节及肺部病变以及腮腺、颌下腺、唇腺的改变;实验室检查方面易出现抗SSB抗体阳性、颗粒型抗核抗体阳性、IgG升高、血沉水平升高。结论：类风湿因子对原发性干燥综合征涎腺、关节及肺部病变具有预测价值。类风湿因子联合涎腺超声可能提高原发性干燥综合征的诊断率,减少唇腺活检等有创检查带来的不便。

Objective： To explore the significance of rheumatoid factor in different clinical manifestations of primary Sjgren＇s syndrome. Methods： The clinical data of 98 cases of primary Sjgren＇s syndrome from Norman Bethune First Hospital of Jilin University from 2014 to 2015 were analyzed and the clinical significance of rheumatoid factor was also explored. Results： The positive rate of rheumatoid factor in primary Sjgren＇s syndrome was 40. 8%. Patients with positive rheumatoid factor were more prone to suffer from fatigue,joint and pulmonary involvement and the change of the parotid gland,salivary gland,labial gland. In terms of the results of laboratory examination,the following were more frequent,including positive anti-SSB antibody and spot type antinuclear antibody,the elevated Ig G level,the increase of erythrocyte sedimentation rate（ ESR）. Conclusion： Rheumatoid factor has a predictive value to salivary gland,joint and pulmonary involvement of primary Sjgren＇s syndrome. The diagnostic performance of primary Sjgren＇s syndrome is probably improved by rheumatoid factor joint salivary gland ultrasonography,which can reduce inconvenience of invasive examination such as labial salivary gland biopsy.