螺内酯联合中药组方治疗早期糖尿病肾病临床研究

Effects of Spironolactone Combining Chinese Medical Herbs on the Treatment of Patients with Stage Ⅲ Diabetic Nephropathy

目的:探讨中西医结合治疗早期糖尿病肾病的用药情况。方法:选取早期糖尿病肾病患者作为研究对象,分为西药组(服用螺内酯)和联合用药组(螺内酯联合中药组方)。检测患者治疗前,治疗结束(2个月),结束后3、6、12个月的血肌酐(Scr)、尿白蛋白排出率(UAER)。结果:西药组和联合用药组治疗结束和结束后随访第3个月时UAER、Scr检测值比治疗前显著下降,差异有统计学意义。联合用药组治疗结束后随访第6、12个月时UAER、Scr检测值比治疗前显著下降,差异有统计学意义。联合用药组在治疗结束、结束后第3、6、12个月时的UAER、Scr检测值都比同一时间点上的西药组低,差异有统计学意义。结论:螺内酯联合中药组方对治疗早期糖尿病肾病特别是中长期疗效有良好的作用。

Objective：To explore the effect of spironolactone combining Chinese medical herbs on the treatment of patients with diabetic nephropathy. Methods：Diabetes patients with stage III diabetic nephropathy were randomized into 2 group （24 cases in each group） . A group was treated with spironolactone, while B group were treated with spironolactone combining Chinese medical herbs both for 2 months. Urinary albumin excretion rate （UAER） and creatinine （Scr） were tested on ex-treatment,at the end of treatment,and the thirth,sixth,12th month after treatment. Results：UAER and Scr of A,B group at the end of treatment,the thirth month after treatment were lower significantly than ex-treatment. UAER and Scr in B group on the point in time the sixth,12th month after treatment were lower significantly than ex-treatment. At the end of treatment, and thirth, sixth, 12th month after treatment, UAER and Scr in B group were lower than those in A group. Conclusion：The long-range effect of spironolactone combining Chinese medical herbs are better than single spironolactone on the patients with stageШdiabetic nephropathy.