扩张型心肌病患者左心室收缩功能障碍的复发率及其影响因素分析

Recurrence Rate of Left Ventricular Systolic Dysfunction of Patients with Dilated Cardiomyopathy and Analysis of Its Influence Factors

目的探究扩张型心肌病(Dilated Cardiomyopathy,DCM)患者左心室收缩功能障碍(Left ventricular systolic dysfunction,LVSD)的复发率,并分析复发的影响因素。方法选择2011年3月—2014年10月在该院接受治疗的DCM出现LVSD并在治疗后恢复的患者109例为观察对象。根据恢复后是否复发分为复发组23例和未复发组86例。对所有患者进行18个月随访,记录复发情况。并对首次入院、首次恢复相关指标进行监测记录。结果在所有恢复患者中有23例复发,复发率为21.10%(23/109)。复发时LVEF水平显著下降,而LVEDD水平显著升高(P<0.05)。根据Logistic回归性分析得到4个影响DCM患者LVSD复发的因素,即:首次恢复中的LVEF、LVEF较基线的增加值、LVEDD以及LVEDD较基线的缩小值等。结论 DCM患者LVSD复发率在21%左右,首次恢复时LVEF、LVEDD改变程度是影响DCM患者LVSD复发的主要因素。

Objective To study the recurrence rate of left ventricular systolic dysfunction of patients with dilated cardiomyopathy and analysis of its influence factors. Methods 109 cases of patients with DCM whose LVSD was recovered after treatment in our hospital from March 2011 to October 2014 were selected as the research objects, and divided into the recurrence group with 23 cases and non-recurrence group with 86 cases according to whether the recurrence occurred or not,and recurrence was recorded after 18-month follow-up, and the related indicators including first admission and first recovery were monitored and recorded. Results Recurrence occurred to 23 cases in all the recovering patients, and the recurrence rate was 21.10%（23/109）, LVEF level obviously decreased and LVEDD level obviously increased at the time of recurrence, all P〈0.05, the Logistic regression analysis showed that 4 influence factors of LVSD recurrence of DCM patients were LVEF in the first recovery, increase value of LVEF compared with the baseline, decrease value of LVEDD and LVEDD compared with the baseline. Conclusion The recurrence rate of LVSD in DCM patients is 21% or so, the change degree of LVEF and LVEDD in the first recovery is the main influence factor of LVSD recurrence of DCM patients.