康妇消炎栓联合阿奇霉素治疗支原体感染盆腔炎的疗效分析

Analysis of curative effects on KangF u XiaoY an suppository combined with azithromycin in the treatment of pelvic inflammation disease complicated by mycoplasma infection

目的探讨康妇消炎栓联合阿奇霉素与单纯使用阿奇霉素治疗支原体感染性盆腔炎的疗效。方法选择2014年1月—2015年12月杭州市妇产科医院妇科门诊收治的112例支原体感染盆腔炎患者为研究对象。按照入院先后将患者分为对照组和治疗组,每组56例。对照组患者给予用阿奇霉素静脉滴注,0.5 g/次,1次/d,2 d后改用阿奇霉素口服制剂0.25 g/d,1次/d。治疗组在上述基础上同时给予康妇消炎栓塞肛,每晚1支。2组患者7 d为1个疗程,一共6个疗程。观察对比2组患者临床效果、用药安全性和外周血T细胞亚群的变化。文中所得数据采用SPSS 17.0统计软件进行处理。结果治疗组患者临床有效率显著优于对照组(χ~2=3.95,P<0.05)。治疗组不良反应发生率为8.93%,低于对照组的12.50%,但差异无统计学意义(P>0.05)。2组患者用药后,血、尿、粪常规、肝功能未见明显异常,安全性较高。治疗后,治疗组外周血T细胞亚群CD4^+百分比为(45.51±5.15)%,显著高于对照组的(43.89±4.06)%,CD8^+百分比为(35.92±3.05)%,显著低于对照组的(37.06±3.25)%、CD4^+/CD8^+比例显著高于对照组,差异有统计学意义。结论康妇消炎栓联合阿奇霉素治疗支原体感染盆腔炎疗效良好,安全性高,不良反应少,外周血T淋巴细胞亚群比例显著改善。

Objective To compare the curative effect of KangFu XiaoYan suppository combined with azithromycin and azithromycin alone in the pelvic inflammation disease complicated by mycoplasma infection. Methods From January,2014 to December,2015,112 cases were selected in our hospital as the research object. According to admission order, 112 patients were divided into the control group（ n = 56）and the treatment group （n = 56 ）. The control group were given intravenous infusion of azithromycin, 0.5 g/times, 1 times/d, 2 days after the use of azithromycin oral preparation, 0.25 g/ times, 1 times/d. Treatment group on the basis of the control group to give KangFu XiaoYan suppository embolism anus, 1 per night. In two groups, 1 courses of treatment is 7 days, a total of 6 courses. After the treatment, the clinical efficacy, safety and changes of T lymphocyte subsets in peripheral blood were compared between the two groups. The data were processed by SPSS 17.0 statistical software. Results The clinical efficiency of the treatment group was significantly better than that of the control group （P 〈 0. 05 ）. The incidence rate of adverse effect in the treatment group was lower than that in control group （ 8.93% vs. 12.50% ）, but the difference was not statistically significant （ P 〉 0. 05 ）. The two groups of patients after treatment, blood, urine, stool, liver function no obvious abnormal, high safety. Treatment of peripheral blood T ceils subsets CD4 ＋ percentages （45.51 ± 5.15% ） was significantly higher than those in control group （43.89% ±4.06% ）, CD8 ＋T cell ratio for（ 35.92% ± 3.05% ） was significantly lower than that in control group （37.06% ±3.25% ）, the ratio of CD4＋/CD8＋ was significantly higher than that of control group, the difference was sta- tistically significant（ P 〈 0. 05 ）. Conclusion KangFu XiaoYan suppository combined with azithromycin in the treatment of pelvic inflammation disease complicated by myeoplasma infection has good curative effects, with safety, few side effects, the proportion of T cell subsets in peripheral blood was significantly improved.