血清VEGF水平与外伤性脑梗死患者预后的相关性分析

The correlation between serum VEGF level and prognosis in traumatic cerebral infarction patients treated by decompressive craniotomy

目的探讨VEGF水平与外伤性脑梗死(TCI)患者预后的相关性。方法选择2011-01—2014-12重型颅脑损伤并发脑梗死患者25例为研究组,选取同期进行健康体检的正常人50例为对照组,研究组行去骨瓣减压术进行治疗,观察研究组患者的临床效果,对比2组治疗前后及不同预后患者的VEGF水平。结果研究组患者治疗前后VEGF水平均显著高于对照组,且术后VEGF水平较术前明显升高,VEGF水平越高随访中GOS评分越低,同时VEGF水平越高,NIHSS评分越高,神经缺损严重程度越高,差异具有统计学意义(P<0.05);经Pearson相关性分析,患者治疗后的VEGF水平与神经功能缺损水平及GOS评分水平均呈正线性相关(相关系数r=0.65、0.71,P<0.05)。结论 TCI患者的血清VEGF水平明显升高,且患者VEGF水平越高预后越差,提示VEGF可作为TCI患者病情、疗效及预后的评价指标。

Objective To investigate the correlation between serum VEGF level and prognosis in traumatic cerebral in‐farction patients treated by decompressive craniotomy .Methods We selected 25 patients with severe brain injury complicated with cerebral infarction from 2011 January to 2014 as study group and at the same time we selected 50 healthy volunteers as control group .Patients in study group were treated with decompressive craniotomy and then we observed the clinical efficacy . And VEGF levels in two groups before and after treatment were compared .Results The VEGF levels before and after treat‐ment in the study group were significantly higher than that in the control group ,and the study group showed higher level after treatment .During the follow-up period ,the higher VEGF level the patients got ,the less GOS scores ,the more NIHSS scores and the severer neurological functional deficit the patients had ,with statistically significant differences （P〈0.05） .Pearson cor‐relation analysis showed that VEGF level after treatment had positive correlations with the severity of neurological functional deficit and the level of GOS scores（correlation coefficient r=0.65 ,r=0.71 ;P〈0.05） .Conclusion The level of serum VEGF in patients with traumatic cerebral infarction may be increased significantly ,and the higher level indicates poor prognosis ,which suggests that VEGF level can be used as indicator to evaluate disease condition ,treatment effect and prognosis .