舒芬太尼联合丙泊酚麻醉在脑动脉瘤栓塞术中的应用效果

Anesthetic effects of sufentanil combined with propofol in patients with cerebral aneurysm treated by arterial embolization

目的探讨舒芬太尼联合丙泊酚麻醉在脑动脉瘤栓塞术中的应用效果。方法选取我院2013-07—2015-07收治的80例脑动脉瘤栓塞术患者,采取随机数字表法分为单独麻醉组与联合麻醉组,每组40例;单独麻醉组仅给予丙泊酚麻醉,联合麻醉组给予舒芬太尼联合丙泊酚麻醉,对比2组患者不同麻醉时间段的平均动脉压(MAP)及心率(HR)水平、自主呼吸与意识恢复时间。结果单独用药组与联合麻醉组T0、T1时间段MAP水平相比无明显差异(t=1.45,P>0.05;t=1.76,P>0.05)。联合麻醉组较单独麻醉组相比T2、T3及T4时间段MAP水平均明显降低(t=2.56,P<0.05;t=2.99,P<0.05;t=3.25,P<0.05)。单独用药组与联合麻醉组T0、T1时间段HR水平相比无明显差异(t=1.76,P>0.05;t=1.89,P>0.05)。联合麻醉组较单独麻醉组相比T2、T3及T4时间段HR水平均明显降低(t=2.89,P<0.05;t=3.45,P<0.05;t=3.38,P<0.05)。单独用药组与联合麻醉组自主呼吸恢复时间与意识恢复时间相比均无明显差异(t=1.71,P>0.05;t=1.65,P>0.05)。结论采用舒芬太尼与丙泊酚联合麻醉应用于脑动脉瘤栓塞术中可获得较为稳定的MAP与HR,麻醉效果显著,不延长自主呼吸及意识恢复时间,值得推广与应用。

Objective To explore anesthetic effects of sufentanil combined with propofol in patients with cerebral aneu- rysm treated by arterial embolization. Methods All selected 80 cases with cerebral aneurysm treated by arterial embolization in our hospital from July 2013 to July 2015 were divided into simple-anesthesia group and united-anesthesia group based on ran-dom number table method. The former group only received propofol and the latter group received sufentanil combined with propofol, Then we compared the mean arterial pressure（MAP）, heart rate（HR）and the recovery time of autonomous respira- tion and consciousness. Results At TO and T1, MAP level did not show significant differences between the two groups（t= 1.45,P〉0.05;t=1. 76,P〉0.05）,but at T2,T3 and T4,the united group presented obviously more decrease relative to the simple group（t=2.56,P〈0.05;t=0.05,P〈0.05;t=0.05,P〈0.05）. Similarly,in terms of HR level,there were no statisti- cal differences between two groups at TO and T1 （t= 1.76,P〉0.05;t= 1.89, P〉0.05）, however, compared to simple group, the united group got lower HR level at the other three time（t= 2.89,P〈0.05;t=0.05,P〈0.05;t=0.05,P〈0. 05）. The recovery time of autonomous respiration and consciousness showed no remarkable differences between the two groups（t= 1.71,P〉1. 71;t= 1.65, P〉0.05）. Conclusion The application of sufentanil and propofol to anesthesia can provide more stable MAP and HR levels for cerebral aneurysm patients treated by arterial embolization with no prolonged recovery time of autono- mous respiration and consciousness,which should be worthy of popularization and application.