掌黑癣1例并中国大陆文献总结

A case report and brief survey of tinea nigra cases reported in China's Mainland

目的报道1例手掌发病的儿童掌黑癣,并文献复习此病临床特点。方法患儿女,5岁9个月,因左手掌黑色斑疹6个月就诊。取局部皮屑完善真菌学检查,分离菌株进行分子生物学鉴定,并文献检索统计在中国大陆报道掌黑癣患者的临床特点。结果分离菌株鉴定结果为威尼克何德霉。总结文献病例9例特点:多见于儿童;左手掌受累比例略多;长江以南为主要发病区域;致病菌均为威尼克何德霉;全部病例外用抗真菌药,3周内治愈。结论掌黑癣主要发生于儿童手掌,镜检可快速诊断,菌种鉴定建议完善分子鉴定,外用抗真菌药膏疗效显著。

Objective We report a case of tinea nigra on the palm of a child and review cases of tinea nigra reported in ma- inland China to date.Methods A 5-year-old girl had noticed pigmented maeulae on the left palm 6 months prior to her first visit to our hospital. Fungal examination with skin scrapings and DNA sequencing with isolation had been done. We also searched literatures about tinea nigra reported in China's Mainland and discussed the clinical characteristics.Results The causa- tive fungus in our case was determined to be Hortaea werneckii.The lesionsof all 9 cases distributed as follows： most cases favorably occurred on the left palm of male children in southern part of Yangtze River.All causative agents were identified as H.werneckii.All cases were cured by topical use of antifungal agents within 3 weeks.Conclusion Tinea nigra is usually oc- curred on one palm of children.And direct microscopic examination is useful for quick diagnosis, Moreover,confirmation of i- dentification depends on DNA sequencing.As for the treatment of tinea nigra,topical antifungal therapy seems to be the best choice.