生殖器疱疹患者健康相关生命质量及其影响因素

Health-related quality of life and influencing factors in patients with genital herpes

目的了解生殖器疱疹患者心理状况、健康相关生命质量(HRQOL)评分,以及HRQOL评分的影响因素。方法对2014年1月—2015年8月大坪医院皮肤科门诊就诊的生殖器疱疹发作期患者进行调查,使用抑郁自评量表(SDS)评估其心理状况,使用生活质量评价量表(SF-36)测量HRQOL评分,分析HRQOL和SDS评分相关性,对HRQOL评分的影响因素进行分析。结果实际调查145例生殖器疱疹患者,HRQOL评分为(479.46±92.45)分,SDS评分为(62.2±14.1)分。其中轻度抑郁者46例(31.73%),中度抑郁者28例(19.31%),重度抑郁者17例(11.73%)。Pearson相关分析显示,受试者HRQOL评分与SDS评分呈负相关(R=-0.37,P<0.001)。多元线性逐步回归法分析结果显示:与HRQOL评分相关的因素按相关程度由大到小依次为接受治疗、知晓生殖器疱疹防治知识、饮酒、年龄、SDS评分、睡眠时间、锻炼(均P<0.05),其中HRQOL评分与年龄、饮酒、SDS评分呈负相关(均P<0.05),与接受治疗、锻炼、知晓生殖器疱疹防治知识、睡眠时间呈正相关(均P<0.05)。结论生殖器疱疹患者普遍出现抑郁心理,HRQOL较差。在临床中应重视年龄偏大和伴发抑郁的患者,并对其进行干预。

Objective To understand the psychological state,health-related quality of life （HRQOL）score,and the influencing factors of HRQOL score in patients with genital herpes.Methods From January 2014 to August 2015,patients with genital herpes in dermatology outpatient clinic of Daping Hospital were investigated,and their psychological status was assessed by self-rating depression scale（SDS）,HRQOL score was measured with the 36-item short form health survey （SF-36）,correlation between HRQOL and SDS score,as well as influencing factors of HRQOL score were analyzed.Results A total of 145 patients with genital herpes were investigated,HRQOL and SDS scores were （479.46±92.45）and （62.2±14.1）respectively.Mild,moderate,and severe depression were 46 （31 .73%）,28（19.31 %）,and 17 （11 .73%）cases respectively.Pearson correlation analysis showed that HRQOL score of the subjects was negatively correlated with SDS score （R =-0.37,P 〈0.001 ）.Multiple linear stepwise regression analysis suggested that the factors related to HRQOL score from large to small were as follows：receive treatment,aware of genital herpes prevention knowledge,drinking,age,SDS score,sleep time,and exercise （all P〈0.05）.HRQOL score was negatively related with age,drinking,and SDS score（all P 〈0.05）,but was positively related with treatment,exercise,aware of genital herpes prevention knowledge,and sleep time（all P 〈0.05 ）. Conclusion Most patients with genital herpes suffer from depression,and with poor HRQOL,more attention mustbe paid to patients of old age and with depression,psychological intervention needs to be performed.