轴突诱导因子4D和血管内皮生长因子在胰腺癌组织中的表达

Clinical significance of the expression of semaphorin 4D and vascular endothelial growth factor in pancreatic carcinoma

目的探讨轴突诱导因子4D(Sema 4D)和血管内皮生长因子(VEGF)在胰腺癌组织中的表达及其临床意义。方法采用免疫组织化学法检测43例胰腺癌组织和10例癌旁组织中Sema 4D和VEGF的表达,分析Sema 4D和VEGF在胰腺癌组织中表达的相关性,以及胰腺癌组织中Sema 4D和VEGF的表达与临床病理特征、患者预后的关系。结果 Sema 4D和VEGF在胰腺癌组织中的阳性表达率分别为51.2%(22/43)和46.5%(20/43),在癌旁组织中的阳性表达率分别为10.0%(1/10)和20.0%(2/10),Sema 4D和VEGF在胰腺癌组织中的阳性表达率均显著高于癌旁组织(P<0.01)。胰腺癌组织中Sema 4D和VEGF的表达呈正相关(r=0.445,P<0.05)。Sema 4D和VEGF的阳性表达均与肿瘤分期、淋巴结转移、脉管内瘤栓有关(P<0.05),与患者的性别、年龄、分化程度、肿瘤直径无关(P>0.05)。VEGF表达阳性者中位生存时间低于VEGF表达阴性者(P<0.05)。Sema 4D表达阳性者中位生存时间与Sema 4D表达阴性者差异无统计学意义(P>0.05)。结论 Sema 4D和VEGF在胰腺癌组织中异常表达可能与胰腺癌的发生发展有一定关系,且二者可能对诱导血管新生具有协同效应;VEGF的表达与胰腺癌预后有关。

Objective To study the clinical significance of the expression of semaphorin 4D （Sema 4D） and vascular endothelial growth factor（VEGF） in pancreatic carcinoma. Methods The expressions of Sema 4D and VEGF in 43 cases of pancreatic cancer and 10 cases of adjacent tissues were detected by immunohistochemistry. The correlation between Sema 4D and VEGF expression in pancreatic cancerwas analyzed. The relationship between Sema 4D or VEGF expression and clinical pathological characteristics or prognosis of patients was analyzed. Results The positive rates of Sema 4D and VEGF in pan- creatic cancer tissues were 51.2% （22/43） and 46.5% （20/43）, and them in adjacent tissues were 10.0% （1/10） and 20. 0% （2/10） ;the positive rates of Sema 4D and VEGF in pancreatic cancer tissues were significantly higher than those in adjacent tissues（ P 〈 0. 01 ）. The expression of Sema 4D was positively correlated with the expression of VEGF in pancreatic cancer tissues （ r = 0.445, P 〈 0.05 ）. The abnormal expression of Sema 4D and VEGF was related to tumor staging, lymph node metastasis and vascular tumor thrombus （ P 〈 0.05 ）, but it was not related to the sex, age, degree of differentiation and tumor size（P 〉0.05）. The live time in patients with positive expression of VEGF was significantly lower than that in patients with negative expression of VEGF （ P 〈 0.05 ）. There was no significant difference in the live time between the patients with positive expression of Sema 4D and the patients with negative expression of Sema 4D （ P 〉 0.05 ）. Conclusions The abnormal expres- sion of Sema 4D and VEGF is related to the occurrence and development of pancreatic cancersex, and Sema 4D and VEGF may have a synergistic effect on the induction of angiogenesis. The expression of VEGF may be related to the prognosis of pancreatic