哮喘儿童诱导痰中TSLP、IL-33的表达及意义

The Levels and Significance of TSLP IL-33,in the Induced Sputum From Children With Asthmatic

目的探讨白介素-33(IL-33)和胸腺基质淋巴细胞生成素(TSLP)在哮喘儿童发病中的作用。方法选择哮喘儿童急性发作期及临床缓解期30例以和正常30例对照,应用ELISA法检测诱导痰中IL-33、TSLP水平,分析两者与嗜酸性粒细胞的相关性。结果急性发作期组和临床缓解期组诱导痰中IL-33和TSLP水平均显著高于正常30例对照组,且急性发作期组显著高于临床缓解期组(P<0.05),差异有统计学意义。IL-33、TSLP与嗜酸性粒细胞呈正相关。结论在儿童哮喘的发生、发展中,IL-33和TSLP起重要作用。

Objective To investigate the roles of interleukin-33（ IL-33） and thymic stromal lymphopoietin（ TSLP）,in the Children with asthma. Methods Active group had 30 patients children with asthma,it was the inactive group they have picked up,and 30 healthy children served as normal controls. IL-33 and TSLP in which were examined by ELISA and correlations between the two indexeswere analyzed. Results Levels of IL-33 and TSLP in asthma group were significantly higher than those in the controlgroup,and which in the exacerbationwere obviously higher than those in the chronic stage（ P〈0. 05）. Conclusion IL-33 and TSLP may play important roles in the occurrence and developmentof asthma.