期刊文献+

联合检测PCT与BNP水平对重症肺炎的临床诊治意义评价 被引量:2

下载PDF
导出
摘要 目的分析并探讨血清降钙素原(PCT)及B型钠尿肽(BNP)对医院获得性肺炎(HAP)重症患者诊断及治疗的价值。方法收集2014年8月~2016年5月152例HAP患者进行研究,76例重症患者为观察组,76例非重症患者为对照组。分别于确诊当天和肺炎治疗结束当天检测两组患者血清PCT与BNP值,监测PCT与BNP的动态变化,评估其对重症肺炎的诊治价值。结果联合检测PCT与BNP对HAP重症患者诊断的受试者工作特征曲线下面积(AUC)为(0.923±0.052)(95%CI:0.865~0.943),灵敏度为82.6%,特异度为94.2%,阳性预测值为93.7%,阴性预测值为73.5%,诊断效能优于各单项指标。HAP重症患者确诊当天、第2天、第3天的PCT及BNP均高于HAP非重症患者(P〈0.05),治疗结束后,两组的PCT及BNP差异无统计学意义(P〉0.05)。结论联合检测PCT与BNP的水平对HAP重症肺炎的发生预测及诊治结局判定有一定的价值。
出处 《中国处方药》 2016年第12期119-120,共2页 Journal of China Prescription Drug
  • 相关文献

参考文献3

二级参考文献135

  • 1Whang KT, Vath SD, Becker KL, et al. Procalcitonin and pro-inflammatory cytokine interactions in sepsis [ J]. Shock,2000,14(1): 73-78.
  • 2Nijsten MW, Olinga P, The TH,et al. Procalcitonin behaves as a fastresponding acute phase protein in vivo and in vitro [ J]. Crit Care Med, 2000, 28 (2): 458461.
  • 3Wiedermann FJ,Kaneider N,Egger P, et al. Migration of human monocytes in response to procalcitonin [J]. Crit Care Med, 2002 , 30(5): 1112-1117.
  • 4Hoffmann G, Totzke G, Seibel M, et al. In vitro modulation of inducible nitric oxide synthase gene expression and nitric oxide synthesis by procalcitonin [J]. Crit Care Med, 2001, 29 (1): 112-126.
  • 5Morgenthaler NG, Struck J, Chancerelle Y,et al. Production of procalcitonin (PCT) in non-thyroidal tissue after LPS injection [J]. Horm Metab Res, 2003 , 35 ( 5): 290-295.
  • 6Meisner M, Tschaikowsky K, Schnabel S, et al. Procalcitonin- influence of temperature,storage,anticoagulation and arterial or venous asservation of blood samples on procalcitonin concentrations [J]. EurJ Clin Chem Clin Biochem, 1997 , 35 ( 8): 597-601.
  • 7Huang DT, Weissfeld LA, Kellum JA, et al. Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia [J]. Ann Emerg Med, 2008 , 52 (1): 48-58.
  • 8Kruger S, Ewig S, Marre R, et al. Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes [J]. Eur Respir J,2008,31 (2): 349-355.
  • 9Hirakata Y,Yanagihara K, Kurihara S, et al. Comparison of usefulness of plasma procalcitonin and C-reactive protein measurements for estimation of severity in adults with community-acquired pneumonia [J]. Diagn Microbiol Infect Dis, 2008 , 61 (2): 170-174.
  • 10Chan YL, Tseng CP, Tsay PK, et al. Procalcitonin as a marker of bacterial infection in the emergency department : an observational study[J]. Crit Care, 2(XM, 8 (1): R12-20.

共引文献891

同被引文献16

引证文献2

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部