敷贴疗法对慢性阻塞性肺疾病稳定期干预的临床研究

Clinical research on point application therapy against stable chronic obstructive pulmonary disease

目的:观察三伏贴和三九贴治疗稳定期慢性阻塞性肺疾病(COPD)的疗效。方法:采用自身前后对照和组间对照的临床试验方法,筛选天津中医药大学第一附属医院呼吸科门诊COPD稳定期患者伏九组100例,三伏组100例。三伏组在常规治疗基础上于每年三伏进行穴位贴敷治疗,伏九组在三伏组治疗基础上于每年三九也进行穴位贴敷治疗。每3个月随访1次,随访2年,观察两组患者急性发作次数、m MRC评分、CAT评分的变化及不良反应发生情况。结果:治疗后两组患者的急性发作次数、m MRC评分、CAT评分与治疗前相比均显著降低(P<0.05)。与三伏贴治疗效果相比,伏九贴治疗效果更优(P<0.05)。两组均未见重大不良反应发生。结论:伏九敷贴疗法对COPD稳定期有较好疗效,能减少急性发作次数,提高患者生活质量,敷贴疗法安全性高,值得临床广泛推广应用。

Objective： To observe the effects of dog days-application and sanjiu-application on the treatment of the stable chronic obstructive pulmonary disease（COPD）. Methods： The controlled clinical study including the self-control and mutual control was designed in this current study. This study included a total of 200 patients with COPD from the respiratory Clinic in the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, who were randomly divided into the dog daysapplication group and sanjiu-application group, each group for 100 cases. Point application therapy was taken on the basis of routine treatment with follow-up every 3 months in 2 years. The times of acute exacerbation, mM RC score, CAT score and adverse reaction were observed. Results： Compared with before the treatment, acute attack times, m MRC score, CAT score of two groupswere decreased after the treatment, and there was statistical significance（P〈0.05）. Moreover, the effects of sanjiu-application were superior to those of the dog days-application（P〈0.05）. No significant adverse reaction was found in both of the two groups. Conclusion： The point application therapy has a good effect on the treatment of stable COPD with high security, which could reduce the frequency of acute attack and improve the life quality. So, it is worthy of extensive promotion and application.