多胺对动物肠道稳态的调控作用及可能机制

Polyamines: Regulation on Intestinal Homeostasis and Possible Mechanisms

多胺(腐胺、亚精胺、精胺等)是动物体内一类具有生物活性的低分子质量脂肪族化合物。多胺能调控动物肠道稳态,参与动物肠道的生长发育、肠道黏膜屏障、抗氧化和代谢等生理过程。但目前多胺调节肠道稳态的作用机理尚不清晰。本文就多胺对肠道稳态的调节作用做一综述,分析了多胺作用的可能机理,旨在为多胺的进一步应用提供参考。

Polyamines（ putrescine,spermidine and spermine,ect.） is a kind of lowmolecular weight aliphatic bioactive compound in animal. Polyamines can regulate intestinal homeostasis,which plays important roles in different physiology procedures,such as intestine growth and development,intestinal mucosal barrier,antioxidant status and metabolism. However,the mechanisms of polyamines regulating intestinal homeostasis are still unknown. Therefore,in order to provide reference for further application of polyamines,regulation effects of polyamines on intestinal homeostasis were reviewed in this paper,and the possible mechanisms were analyzed.