摘要
免疫检查点抑制剂应用作为一种新型的抗肿瘤疗法,是恶性肿瘤治疗史上一个里程碑式的创新。研究发现,抑制免疫检查点对胃肠肿瘤的治疗也十分有效。为了提高免疫治疗的疗效,一些不同的治疗方案正在研究评估中。本文总结了2014年欧洲癌症研究与治疗组织(European Organization for Research and Treatment of Cancer,EORTC)召开的胃肠道肿瘤转化研究会议和近两年美国临床肿瘤学会(American Society of Clinical Oncology,ASCO)年会的相关讨论内容,并从免疫细胞浸润与新分子靶点、免疫检查点抑制剂、免疫治疗遗传标志、免疫检查点抑制剂与溶瘤病毒组合以及个体化免疫治疗这5个方面对胃肠肿瘤免疫治疗的最新研究进展进行综述。
As a new type of antitumor therapy, the use of immune checkpoint inhibitors is a landmark innovation in the treatment of malignant tumors. Previous studies suggest that the immune checkpoint inhibition might be also effective in patients with gastrointestinal cancer. In order to improve the efficacy of immunotherapy, several different strategies are currently under evaluation. In this review, the related discussions in European Organization for Research and Treatment of Cancer （EORTC） Gastrointestinal Tract Cancer Translational Research Meeting in 2014 and American Society of Clinical Oncology （ASCO） annual meeting in the resent two years are summarized. Moreover, the paper reviews the latest clinical research progress about the immunotherapy of gastrointestinal cancers from five aspects： the infiltration of immune cells and new molecular targets, immune checkpoint inhibitors, genetic marker for immunotherapy, combination of checkpoint inhibitors and oncolytic virus, and individualized immunotherapy,
出处
《肿瘤》
CAS
CSCD
北大核心
2016年第11期1280-1286,共7页
Tumor
关键词
胃肠肿瘤
肿瘤辅助疗法
免疫治疗
免疫检查点抑制剂
Gastrointestinal neoplasms
Neoadjuvant therapy
Immunotherapy
Immune checkpoint inhibitors
