Caspase-7与视网膜缺血-再灌注损伤

Caspase-7 and retinal ischemia-reperfusion injury

视网膜缺血-再灌注损伤是细胞凋亡、炎症反应等多种机制参与的病理生理过程。半胱氨酸蛋白酶7(Caspase-7)是Caspase家族中的凋亡效应分子,近期研究表明,它在调控炎症细胞因子方面也起着重要作用。本文就Caspase-7生物学特性及其与细胞凋亡、炎症反应在视网膜缺血-再灌注损伤的分子机制进行综述。

Retinal ischemia-reperfusion injury is a pathophysiologicat process in- volved by cell apoptosis,inflammation, and many other mechanisms. Caspase-7, one ap- optosis executioner in Caspase family,plays an important role in modulating inflamma- tory cytokines as many researches have proved recently. This article reviews the biologi- cal characteristics of Caspase-7, molecular mechanisms between Caspase-7 and cell ap- optosis as well as inflammation in retinal ischemia-reperfusion injury.