基于微混合器的连续混合技术在丹参醇沉过程中的应用

Application of continuous mixing technology in ethanol precipitation process of Salvia miltiorrhiza by using micromixer

连续制药是国际制药技术领域的发展方向之一。该研究采用膜分散法实现了丹参醇沉中加醇过程的连续化,考察了乙醇和浓缩液流量,以及醇料比等因素对醇沉效果的影响。乙醇和浓缩液流量增加能提高酚酸类活性成分的保留率,降低总固体去除率。醇沉上清液中活性成分纯度主要受到乙醇和浓缩液流量比影响。该研究中连续流动加醇的混合效果与工业醇沉相当。以膜分散混合器实现连续加醇,具有放大容易,单位体积处理量大,加醇过程稳态易控等优点,发展前景良好。

Continuous pharmaceutical manufacturing is one of the development directions in international pharmaceutical technology. In this study,a continuous mixing technology of ethanol and concentrated extract in the ethanol precipitation of Salvia miltiorrhiza was realized by using a membrane dispersion method. The effects of ethanol flowrate,concentrated extract flowrate,and flowrate ratio on ethanol precipitation results were investigated. With the increase of the flowrates of ethanol and concentrated extract,retention rate of active phenolic acids components was increased,and the total solid removal rate was decreased. The purity of active components in supernatants was mainly affected by the ratio of ethanol flowrate and concentrated extract flowrate. The mixing efficiency of adding ethanol under continuous flow mixing mode in this study was comparable to that of industrial ethanol precipitation. Continuous adding ethanol by using a membrane dispersion mixer is a promising technology with many advantages such as easy enlargement,large production per unit volume,and easy control.