红霉素不同给药方案对新生儿喂养不耐受比较

Different Dosage Regimens of Erythromyc in Treatment of Neonatal Feeding Intolerance

目的:探讨红霉素不同给药方案对新生儿喂养不耐受的治疗效果。方法:我院于2015年1月至2016年1月收治的342例新生儿患者的临床资料,其中42例患者为喂养不耐受者,随机分为2组:第1组(小剂量红霉素,1次/d)21例,第2组(小剂量红霉素,2次/d)21例,比较2组患者的治疗效果和安全性。结果:喂养不耐受在住院新生儿中总体发生率为12.28%,足月儿、>2 000 g早产儿和≤2 000 g早产儿患者喂养不耐受的发生率具有显著性差异(χ2=12.742,P<0.01)。红霉素5 mg/(kg·次),1次/d给药与2次/d给药的治疗效果基本相当,组间无显著性差异(P>0.05)。结论:红霉素5 mg/(kg·次),1次/d给药与2次/d给药的治疗效果基本相当,因此可酌情考虑采用红霉素5 mg/(kg·次),1次/d给药方案治疗新生儿喂养不耐受,该法安全可靠,值得临床应用。

Objective：To investigate the therapeutic effect of different dosage regimens of erythromycin on neonatal feeding intolerance.Methods：A retrospective analysis was made in 342 cases of neonates from January 2015 to January 2016.Of them, 42 cases had feeding intolerance and were randomly divided into two groups ： group 1 （ low-dose erythromycin , once daily ） and group 2 （low-dose erythromycin, twice daily）, 21 cases in each group.The efficacy and safety were compared between the two groups.Results：The overall incidence of feeding intolerance in hospitalized neonates was 12.28%, and there was a significant difference in the incidence of feeding intolerance among full-term infants, 〉2 000 g premature infants and ≤2 000 g premature infants （χ^2 =12.742, P〈0.01）.Given erythromycin of 5 mg/（kg·time）, once daily regimen and twice daily regimen had no significant difference in therapeutic effect （P〉0.05）.Conclusion：Given erythromycin 5 mg/（kg· time）, the efficacy of once daily regimen is as equal as that of twice daily regimen .Therefore, the regimen of erythromycin 5 mg/（kg·time）,once daily can be considered in the treatment of neonatal feeding .It is safe, reliable and worthy of clinical application .