清肺健脾理气解毒汤联合西药治疗呼吸机相关性肺炎的临床研究

Clinical Study on Ventilator Associated Pneumonia Treated with Qingfei Jianpi Liqi Jiedu Tang(清肺健脾理气解毒汤) Combined with Western Medicine

目的:观察中药清肺健脾理气解毒汤联合西药治疗呼吸机相关性肺炎的临床疗效。方法:将47例呼吸机相关性肺炎患者随机分为观察组及对照组。2组均给予呼吸机干预策略。观察组在此基础上予清肺健脾理气解毒汤鼻饲14 d。观察2组患者治疗前后的中医证候积分、肺部感染评分变化及T淋巴细胞亚群、WBC、血清降钙素原、超敏C-反应蛋白的变化。结果:观察组总有效率100%,对照组总有效率72.7%。2组患者治疗效果比较,差异有统计学意义(P<O.05);2组患者治疗后WBC、CRP、PCT、中医证候积分及CPIS较治疗前下降明显,差异有统计学意义(P<0.05);观察组治疗后外周血CD+3、CD+4细胞计数较治疗前明显增高,2组比较差异有统计学意义(P<0.05)。结论:清肺健脾理气解毒汤联合西药治疗呼吸机相关性肺炎的临床疗效显著。

Objective： To observe the curative effect of combination of traditional Chinese medicine Qingfei Jianpi Liqi Jiedu Tang and Western medicine in the treatment of ventilator associated pneumonia. Methods： 47 patients with ventilator associated pneumonia were randomly divided into two groups： observation group and control group. Two groups were treated with ventilator in Cambodia intervention strategies,the observation group patients were given Qingfei Jianpi Liqi Jiedu Tang for nasal feeding on the basis of treatment for 14 days. The syndrome in Chinese medicine points and clinical pulmonary infection score（ CPIS） changes were recorded before and after treated,the changes of T lymphocyte subsets,WBC,serum levels of super sensitive C- reactive protein and procalcitonin（ PCT） were determined. Results： The total effective rate of observation group was 100%,and the control group was 72. 7%,the difference between the two groups was statistically significant（ P〈0. 05）.The syndrome in Chinese medicine points and CPIS,WBC,CRP and PCT were all decreased obviously in the two groups,the differences were significant to compare with pro- treatment（ P〈0. 05）. CD＋3and CD＋4in the observation group were raised significantly,the differences were significant to compare with control group（ P〈0. 05）. Conclusion： Chinese medicine Qingfei Jianpi Liqi Jiedu Tang can improve the curative effect of ventilator associated pneumonia.