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EDIL3/Del-1因子与肿瘤的发生、发展过程关系的研究进展 被引量:3

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摘要 EDIL3/Del-1(EGF-like repeats and discoidin I-like domains 3/Developmental endothelial locus-1)是一种内皮细胞分泌的独特的αVβ3整合素配体,其在胚胎细胞中进行短暂的表达,并且可以调节细胞间的粘附、细胞的迁移以及激活细胞间主要的信息交往过程中的胞质信号分子.在EDIL3/Del-1分子的促瘤作用中还发现其可以促进肿瘤淋巴管的生长,抑制细胞凋亡,调节上皮细胞间质转型,此外其发挥作用还与内皮细胞生长因子及炎症有关.现在对EDIL3/Del-1的研究已逐渐深入,从相关的描述性研究已深入到了分子机制的探讨,在此对这种因子在肿瘤发生、发展方面的关系的研究进展作一综述.
出处 《国际泌尿系统杂志》 2016年第6期916-920,共5页 International Journal of Urology and Nephrology
基金 甘肃省自然科学基金(1506RJZA252)
关键词 肿瘤 糖蛋白类
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