喜炎平雾化吸入治疗小儿毛细支气管炎疗效的系统评价

Systematic evaluation of Xiyanping aerosol inhalation for pediatric bronchiolitis

目的系统评价喜炎平雾化吸入治疗小儿毛细支气管炎的有效性、安全性。方法计算机检索Cochrane library、Embase、Pubmed、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数字化期刊全文库(各数据库检索时间均自建库至2016年3月),收集喜炎平雾化吸入治疗小儿毛细支气管炎的随机对照试验,对符合纳入标准的临床研究进行方法学质量评价和Meta分析。结果共纳入11个研究,共1068例患儿,治疗组共550例,对照组共518例。Meta分析结果显示,与对照组比较,喜炎平雾化吸入在提高总有效率、缩短咳嗽消失时间、缩短哮鸣音消失时间、缩短喘憋时间方面均显示出较好的疗效(P<0.01);2组的安全性差异无统计学意义(P>0.01)。结论喜炎平雾化吸入治疗小儿毛细支气管炎的有效性高于对照组,但由于本文纳入研究质量偏低,尚需大样本、高质量的随机对照双盲试验进一步论证。

Objective To evaluate the safety and effectiveness of aerosol inhalation of Xiyanping for pediatric bronchiolitis. Methods The Cocharane library, Embase, Pubmed, CNKI, VIP and Wanfang data（from the foundation date to March 2016） were searched for randomized controlled trials（RCTs） of Xiyanping aerosol inhalation for bronchiolitis in children. The methodological quality and Meta-analysis of the included trails according to the inclusion and exclusion criteria were assessed. Results Eleven randomized controlled trials were included, totally 1068 children（550 in the observation group and 518 in the control group）. The combined analysis showed that the total effective rate, and the disappearing time of cough, wheeze and dyspnea in the Xiyanping group were better than those in the control group, with significant difference（P 〈 0.01）. There was no significant difference in the incidence of adverse reactions in the 2 groups（P 〉 0.01）. Conclusion For pediatric bronchiolitis, Xiyanping aerosol inhalation is better than the controls in the efficacy in current study. Randomized controlled trials with large samples and high quality methodology are needed to confirm these results.