石家庄地区不孕不育相关染色体分析

Chromosome results analysis of infertility in Shijiazhuang region

目的探讨染色体数目、结构和多态性异常与不孕不育临床表现的关系。方法按照常规G显带方法制备外周血淋巴细胞染色体,并对其核型进行数目和结构的分析,必要的做C显带和Y染色体微缺失。结果 7658例不孕不育病例中251染色体核型异常,异常率为3.28%,其中数目异常93例,结构异常158例,比例分别为1.22%、2.06%,染色体多态性630例,比例为8.23%。结论细胞学遗传学对于不孕不育患者在优生优育中具有指导意义。

Objective：To investigate the abnormal chromosome number,structure and polymorphism with infertility clinical manifestation. Methods：According to the conventional preparation of peripheral blood lymphocyte chromosome G banding methods,and the number and structure of its karyotype analysis,C banding and micro-absence of Y chromosome necesarily. Results：In 7658 cases of infertility cases,251 abnormal chromosome karyotype,the abnormal rate was 3.28%,among which 93 were abnormal number and structural abnormalities in 158 cases,the abnormal rate was respectively 1.22%,2.06%,630 cases of chromosomal polymorphism,the abnormal rate was 8.23%. Conclusion：Cytological genetics for infertility patients has a guiding significance in birth health.