抗苗勒管激素水平在不同卵巢储备功能的女性之间的差异研究

Study on the difference of anti-Müllerian hormone levels among women with different ovarian reserve function

目的检测抗苗勒管激素(AMH)在卵巢早衰(POF)、多囊卵巢综合征(PCOS)患者以及正常健康女性血清中的变化水平并探讨其在产前筛查方面的临床意义与价值。方法选取本院POF患者(POF组)39例,PCOS患者(PCOS组)42例,并选取同期接受健康体检且月经周期正常的女性45例作为对照组。测定上述3组女性血清中AMH、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)及睾酮(T)的水平。结果 PCOS组AMH、E2和T水平高于POF组和对照组,而对照组AMH和E2水平高于POF组,差异有统计学意义(P<0.05);POF组FSH、LH高于PCOS组和对照组,而PCOS组LH高于对照组,差异有统计学意义(P<0.05),PCOS组与对照组FSH相比无统计学差异(P>0.05)。结论 AMH在不同卵巢储备功能的PCOS、POF患者以及正常健康女性中表达水平不同,因而联合检测血清中AMH与性激素水平在诊断PCOS和POF以及产前筛查方面具有一定的临床应用价值。

Objective： To investigate the diversity of anti-Mtlllerian hormone （AMH） levels between people with premature ovarian failure （POF） , polycystic ovary syndrome （PCOS） and normal healthy women and to understand its clinical significance and value in prenatal screening. Methods： Thirty-nine patients with POF （Group POF） and forty-two patients with PCOS （Group PCOS） were included in this study, and forty-five women with normal menstrual cycle were selected as the control group. The levels of AMH, follicle stimulating hormone （FSH） , luteinizing hormone （LH） , estradiol （E2） and testosterone （T） in the serum of the three groups were measured. Results： Our results showed that the levels of AMH, E2 and T in group PCOS were significantly higher than those in the group POF and control group, while the levels of AMH and E2 in the control group were significantly higher than those in the group POF （P〈0.05） ： The levels of FSH and LH in the group POF were significantly higher than those in the group PCOS and control group （P〈0.05） , and the group PCOS had higher LH level than the control group （P〈0.05） ： The levels of the FSH were no significant difference between the group PCOS and the control group （P〉 0.05） ： Conclusion： AMH showed variable expression levels in different ovarian reserve function of PCOS, POF patients and normal healthy women. Therefore, a joint detection of serum AMH and sex hormone levels in the PCOS / POF diagnosis and prenatal screening have a certain clinical diagnostic and application value.