威海市立医院2015年儿科门诊抗热性惊厥药物使用情况调查

Survey on anticonvulsant drug use in pediatric outpatients of Weihai municipal hospital in 2015

目的:分析、探讨精神类药品在预防、治疗小儿热性惊厥中的应用情况,试评价其有效性、安全性及经济性,为临床合理用药提供依据。方法:回顾性分析239例热性惊厥(FS)患儿的一般资料、不良反应发生率、惊厥复发情况和治疗费用。结果:239例热性惊厥患儿中单纯型热性惊厥(SFS)患儿预防用药率为92.4%,复杂型热性惊厥(complicated feverseizures,CFS)患儿预防用药率为100%。主要使用药物为巴比妥类药物。苯巴比妥与地西泮在防治小儿热性惊厥的有效率、治疗费用方面差异无统计学意义(P>0.05);但是,地西泮较苯巴比妥不良反应发生率、惊厥复发率低,差异有统计学意义(P<0.05)。结论:239例热性惊厥患儿中,92.4%的单纯型热性惊厥患儿预防用药率偏高,止惊、预防用药基本合理。

Objective: To determine the use situation of anticonvulsant drugs in pediatric outpatients of Weihai Municipal Hospital in 2015,and analyze their effectiveness,safety and economy so as to provide a basis for clinical rational medication. Methods:The general information of 239 children with fever seizures( FS),the incidence rate of adverse drug reactions,FS recurrence and the costs were retrospectively analyzed. Results: Among the 239 children,the rates of preventive medications in simple fever seizures( SFS) and complicated fever seizures( CFS) were 92.4% and 100%,respectively. The Barbiturates were commonly used. There were no statistical differences in the effective rate and treatment costs of Diazepam and Phenobarbital in the treatment of the children with FS( P>0.05); however,the incidence rate of adverse drug reactions and FS recurrence rate of Diazepam were lower than those of Phenobarbital,and the differences were statistically significant( P<0.05). Conclusions: Among the 239 children with FS,the rate of preventive medications in SFS is high,but the choice of the anticonvulsant drugs in the treatment and prevention of convulsions isreasonable basically.