丹蒌片对急性ST段抬高型心肌梗死患者PCI术后炎症反应的临床疗效观察

To Observe the Clinical Efficacy of Danloutablets on Inflammatory Reaction of Acute ST Elevation Myocardial Infarction Patients After PCI Operation

目的探讨丹蒌片对急性ST段抬高型心肌梗死患者PCI术后炎症反应的临床疗效观察。方法收集该院2013年2月—2015年3月治疗的急性ST段抬高型心肌梗死患者65例,随机分成试验组33例,对照组32例,两组患者术前常规均阿司匹林300 mg嚼服,氯吡格雷600 mg口服。PCI治疗后,两组患者在常规治疗的基础上给予他汀类药物治疗,试验组口服丹蒌片5粒/次,对照组给予等量的安慰剂。结果两组患者治疗前的血清超敏C-反应蛋白(Hs CRP)、五聚素(PTX-3)水平比较差异无统计学意义(P>0.05);治疗后两组比较,差异均有统计学意义(P<0.05)。两组患者术后即刻行心脏彩超LVDd及EF水平的比较,差异均无统计学意义(P>0.05);术后15 d和30 d的LVDd水平较前明显降低,两组比较均有统计学意义(P<0.05)。中医临床证候评定两组比较差异均有统计学意义(P<0.05)。结论丹蒌片能够降低急性ST段抬高型心肌梗死患者的炎症反应,改善患者的临床症状,提高远期预后,改善中医临床证候。

Objective To investigate the Danlou tablets observation on the clinical curative effect of inflammation in patients with acute ST segment elevation myocardial infarction in patients undergoing percutaneous coronary intervention（PCI） after operation. Method Collect our hospital in February 2013 to March 2015 in the treatment of acute ST segment elevation myocardial infarction（STEMI） in65 cases, were randomly divided into experimental group（n = 33, 32 in the control group, two groups of patients with preoperative routine were aspirin 300 mg chewing clopidogrel 600 mg oral. PCI after treatment, two groups of patients in the conventional treatmentbased on the given statin treatment, experimental group received oral Danlou tablets 5 grains / time, control group received an equivalent volume of placebo. Results before treatment, the patients in the two groups of serum high-sensitivity C-reactive protein（hs CRP）,poly（Ptx-3 level there is no had no statistical significance（P〉0.05）; after treatment two groups. The differences were statistically significant（P〈0.05）. Two groups of patients after underwent immediate echocardiographic LVDD and LVEF level comparison, the difference was not statistically significant（P〉0.05）; 15 th day and the 30 th day after the operation of LVDD level was significantly decreased than before, two group comparisons were statistically significant（P〈0.05）. TCM clinical syndrome assessment of the two groups were statistically significant（P〈0.05）. Conclusion Danlou tablets can reduce the acute ST segment elevation myocardial infarction in patients with inflammatory reaction, improve the patient＇s clinical symptoms and improve the long-term prognosis and improve the clinical syndromes of traditional Chinese medicine.