痛泻要方治疗溃疡性结肠炎的药理机制研究

Study of Tong Xie Prescription in the Treatment of Ulcerative Colitis

目的：探讨痛泻药方治疗溃疡性结肠炎（UC）的药理作用机制.方法：将大鼠随机分为4组,模型对照组,模型组,痛泻药方高剂量组和低剂量组,每组10只.TNBS法建立溃疡性结肠炎大鼠模型,通过评估各组大鼠肠道损伤程度,IL-6和NF-κB水平探讨痛泻药方的治疗作用及机理.结果：模型组损伤评分明显高于对照组,治疗组损伤评分明显低于模型组,且高剂量组损伤评分明显低于低剂量组,且差异有统计学意义（P＜0.05）.模型组IL-6,NF-κB水平明显高于对照组,治疗组IL-6,NF-κB水平明显低于模型组,且高剂量组IL-6,NF-κB水平明显低于低剂量组,且差异有统计学意义（P＜0.05）.结论：痛泻药方对UC的治疗作用与其调节UC中异常的IL-6及NF-κB水平的药理作用相关.

OBJECTIVE ： To discuss the pharmacological mechanism of Tong Xie prescription in the treatment of ulcerative coli- tis. METHODS： All the rats were randomly divided into 4 groups, including solvent control group, model group, high dose group and low dose group. The rat model of ulcerative colitis was established by TNBS method. The degree of intestinal damage of rats in each group was evaluated in order to discuss the therapeutic action and mechanism of Tong Xie prescription. RESULTS： The injury score in model group was significantly higher than that in control group, while the ones in treatment group and high dose group were significantly lower than those in model group and low dose group. Meanwhile, the IL -6 and NF - KB levels in the above groups were the same too. There were statistically significant differences （P 〈 0. 05 ）. CONCLUSION ： Tong Xie prescription can treat UC effectaly.