小儿哮喘急性发作应用沙丁胺醇联合布地奈德治疗的效果评价

Pediatric Asthma Acute Joint Budesonide Albuterol Treatment Effect Assessment

目的探讨沙丁胺醇与布地奈德联合治疗小儿哮喘急性发作的效果。方法选取我院2013年1月至2015年5月接诊的小儿哮喘急性发作患儿160例进行研究,家属均接受本研究并签署知情同意书,按照随机数字法将他们分为2组,各80例。对照组患儿采取常规治疗,而研究组患儿除了予以常规治疗外,还加用沙丁胺醇与布地奈德联合治疗。观察记录两组患儿临床效果、症状(咳嗽、肺部哮鸣音、呼吸困难)消失时间,以及治疗前后肺功能指标变化,并对比分析。结果研究组患儿总有效率为92.50%,显著高于对照组的75.00%(P<0.05);研究组患儿咳嗽、肺部哮鸣音及呼吸困难消失时间均明显短于对照组(P<0.05);研究组患儿治疗后第一秒最大呼气量(FEV1)、用力肺活量(FVC)、肺活量(VC)及呼气峰流速(PEFR)均有明显改善(P<0.05),且治疗后明显优于对照组(P<0.05),而对照组无明显改善(P>0.05)。结论沙丁胺醇与布地奈德联合治疗小儿哮喘急性发作不仅疗效明显,而且可更快地改善症状,并明显改善肺功能,值得推广。

Objective To study the salbutamol and budesonide combined effect for the treatment of pediatric acute attack of asthma.Methods From January 2013 to May 2015 departments of 160 cases of children with acute pediatric asthma,family mem-bers accept and sign the informed consent in this study,they can be divided into two groups according to random number method, 80 cases each.Control group take regular treatment,children and children with the team in addition to conventional treatment,also used a combination of salbutamol and budesonide.Observed two groups of children with clinical effect,the symptoms disappear （cough,lung wheezing sound,difficulty in breathing）,and lung function indexes before and after treatment,and comparative analy-sis.Results The team with the total effective rate was 92.50%,significantly higher than that of control group 75.00%（P〈0.05）;Group of children cough,lung wheezing sound and breathing difficulties disappear time were significantly shorter than the control group（P〈0.05）;The team the first seconds after treatment in children with maximum expiratory volume （FEV1） and forced vital capacity （FVC）,forced vital capacity（VC） and peak expiratory flow rate（PEFR） were improved significantly（P〈0.05）,and is superior to control group after treatment （P〈0.05）,while the control group no significant improvement （P〉0.05）.Conclusion Salbutamol and budesonide combined treatment of pediatric asthma acute curative effect obviously,not only but also can improve the symptoms of more quickly,and obviously improve pulmonary function,is worth promoting.