丹参酮ⅡA联合少腹逐瘀颗粒对子宫内膜异位症的疗效观察

Therapeutic effects of tanshinone IIA combined with Shaofuzhuyu particles on endometriosis

目的探讨丹参酮ⅡA联合少腹逐瘀颗粒对腹腔镜术后子宫内膜异位症患者的疗效及对患者血清血管内皮生长因子（VEGF）、肿瘤坏死因子、OL（TNF-α）、白细胞介素-8（IL-8）和白细胞介素-6（IL-6）的影响。方法收集行腹腔镜手术确诊为子宫内膜内畀症患者106例，随机分为对照组和实验纽，每组53例。两组患者均实施腹腔镜手术，对照组术后给予丹参酮ⅡA，实验组在对照组治疗基础上给予少腹逐瘀颗粒。治疗结束后观察两组患者的疗效以及患者血清VEGF、TNF-α、IL-8和IL-6含量的变化。结果实验组总有效率为92．45％，对照组为75．47％，两组比较差异有统计学意义（P〈0．05）；实验组患者血清中VEGF、TNF-α、IL-8和IL-6含量较治疗前明显降低，且低于对照组，差异均有统计学意义（P〈0．05）。结论丹参酮ⅡA联合少腹逐瘀颗粒可增加腹腔镜术后子宫内膜异位症的治愈率，其作用机制可能与降低患者血清中VEGF、TNF-α、IL-8和IL-6的水平有关。

Objective To observe the therapeutic effects of tanshinone Ⅱ A combined with Shao- fuzhuyu particles on endometriosis after laparoscopy, and its effects on the levels of VEGF, TNF - α, IL -8 and IL -6. Methods A total of 106 patients with endometriosis who treated by laparoscopic sur- gery were divided into treatment group and control group, with 53 cases in each group. The patients in control group were treated with tanshinone Ⅱ A, and the patients in treatment group were treated with tan- shinone Ⅱ A and Shaofuzhuyu particles after laparoscopic surgery. The therapeutic effects and the levels of VEGF, TNF - α, IL - 8 and IL - 6 of the two groups after treatment were observed. Results The total effective rate of control group was 75.47%, and the total effective rate of treatment group was 92.45%, the difference was significant（P 〈 0.05 ）. The levels of VEGF, TNF -α, IL -8 and IL -6 after treat- ment in treatment group were significantly lower than those before treatment（ P 〈0.05 ）, and the levels of VEGF, TNF - a, IL - 8 and IL - 6 in the treatment group were significantly lower than those in the con- trol group （P 〈 0.05 ）. Conclusions Tanshinone 11 A and Shaofuzhuyu particles can effectively improve the curative effect of endometriosis after laparoscopic surgery by decreasing the levels of VEGF, TNF - α, IL - 8 and IL - 6.