冠心病痰热互结证与血清hs-CRP、IL-6水平相关性研究

Association between coronary heart disease with intermingled phlegm-heat syndrome and serum levels of high-sensitivity C-reactive protein and interleukin-6

目的:探讨冠心病痰热互结证与血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)水平的相关性。方法:将诊断为冠心病痰热互结证患者34例、冠心病气虚血瘀证患者30例、健康居民26例分为3组,空腹取静脉血,采用免疫透射比浊法检测血清hs-CRP水平、放射免疫分析法检测血清IL-6水平。结果:冠心病痰热互结组血清hs-CRP、IL-6的水平高于冠心病气虚血瘀组和对照组,差异均有统计学意义(P<0.01)。结论:血清hs-CRP、IL-6的水平与冠心病痰热互结证有一定的相关性。

Objective： To investigate the association between coronary heart disease（ CHD） with intermingled phlegm-heat syndrome and serum levels of high-sensitivity C-reactive protein（ hs-CRP） and interleukin-6（ IL-6）. Methods： A total of 34 CHD patients with intermingled phlegm-heat syndrome,30 CHD patients with qi-deficiency and blood-stasis syndrome,and 26 healthy residents were enrolled as three groups. Fasting venous blood samples were collected,and turbidimetric immunoassay and radioimmunoassay were used to measure the serum levels of hs-CRP and IL-6,respectively. Results： The intermingled phlegm-heat syndrome group had significantly higher serum levels of hs-CRP and IL-6 than the qi-deficiency and blood-stasis syndrome group and the control group（ P 〈0. 01）. Conclusion： There is certain association between serum levels of hs-CRP and IL-6 and coronary heart disease with intermingled phlegm-heat syndrome.