南京地区斑贴变应原种类的初步筛选

Screening for contact-allergens with patch test in Nanjing city

目的:筛选南京地区的斑贴变应原种类。方法:参照曲泰斯及国际接触性皮炎研究组提供的标准,并以前期文献分析数据为依据,制备40种斑贴变应原。纳入443例接触性皮炎(湿疹)患者,先后给予曲泰斯和自制斑试变应原检测,观察两组斑试变应原在患者中阳性率差异,以评估在临床应用的可行性。结果:自制斑试变应原总体阳性率低于曲泰斯(73%&81.7%),二者差异具有统计学意义(P<0.05);相同的斑试变应原相比,12种自制斑贴试剂单个变应原检测阳性率低于曲泰斯;除常规检测的24种斑贴变应原外,另外检测到16种阳性率较高斑贴变应原,也是南京地区常见的接触过敏原。结论:除曲泰斯标准变应原系列提及的24种变应原外,另16种阳性率较高的变应原可同时纳入南京地区筛选抗原系列。

Objective：To screen the contact-allergens with patch test in Nanjing. Methods：Forty domes-tic allergens were prepared according to TRUE Test standard patch testing series（ 24） and the criterion provid-ed by the international contact dermatitis research group, and on the base of literature review. Four hundred and forty-three patients of contact dermatitis were enrolled into the study and were tested with TRUE Test patch testing series and domestic patch test to compare the positivity rates between the two tests. Results：The positivity rate of domestic allergens was lower than that of TRUE Test patch testing series （73% ＆ 81.7%）, with a significant difference （ P〈0.05） . When tested with the same12 allergens, the positivity rate was lower in domestic allergens than in TRUE Test patch testing series. Apart from 24 common-used allergens, another 16 domestic allergens had higher positivity rate （ might be common allergens in Nanjing） Conclusion：Except twenty four domestic allergens mentioned in the TRUE Test standard patch testing series,another sixteen aller-gens can be enrolled in the screening allergen in Nanjing city.