平均血红蛋白浓度与代谢综合征及其组分间的相关性研究

The correlation between MCHC and metabolic syndrome components

目的探讨平均血红蛋白浓度与代谢综合征及其组分之间的关联。方法选取北京市小汤山医院2012年参加体检的28 057人为研究对象,其中男性17 268人,年龄（46.81±14.01）岁,女性10 789人,年龄（43.68±13.52）岁。用Person相关分析研究平均血红蛋白浓度与代谢综合征及其组分之间的关联性,并按照平均血红蛋白浓度的四分位数将研究对象分为4组,进行二分类logistic回归分析,探讨平均血红蛋白浓度水平对代谢综合征患病风险的影响。结果代谢综合征组人群的平均血红蛋白浓度高于未患代谢综合征组人群,差异有统计学意义（P〈0.01）;Person相关分析显示,平均血红蛋白浓度与体质量指数、收缩压、舒张压、甘油三酯、空腹血糖水平均呈正相关（P〈0.01）,与高密度脂蛋白水平呈负相关（P〈0.01）;在控制年龄、性别和代谢综合征其他组分后的偏相关分析中,收缩压、舒张压、甘油三酯、空腹血糖和高密度脂蛋白的相关性依然存在（P〈0.01）;logistic回归分析结果显示,在控制年龄、性别后,随着平均血红蛋白浓度的升高,患代谢综合征的风险增加,且差异均有统计学意义（P〈0.05）,与第1组（平均血红蛋白浓度最低组）比较,第2组的OR值（95%CI）为1.190（1.085-1.306）,第3组的OR值（95%CI）为1.547（1.405-1.702）,第4组的OR值（95%CI）为2.243（2.039-2.466）。结论平均血红蛋白浓度与代谢综合征及其组分间存在相关性,是代谢综合征及其组分异常的风险因素。

Objective To explore the association of MCHC with metabolic syndrome and its components.Methods A total of 28 057 individuals in Beijing Xiaotangshan hospital were recruited in the study.There were17 268males（average 46.81±14.01 years old）and 10 789females（average 43.68±13.52 years old）.Person was used to analyze the correlation of MCHC with MS and its components.The subjects were divided into four quartiles according to MCHC.Binary logistic regression was applied for data analysis. Results The average MCHC was higher in subjects with MS（344.82±10.39g/L）compared to individuals without MS（341.10±10.36g/L）（P〈0.01）.Person analysis showed that there were positive correlation between MCHC and major components of MS,Such as BMI,SBP,DBP,TG and FPG（P〈0.01）.While a negative correlation was found between MS and HDL（P〈0.01）.Binary logistic regression analysis revealed that an elevated MCHC was positively correlated with high risk of MS after adjusting for age and sex.Compared to individuals with the lowest MCHC,subjects with higher to highest MCHC were more vulnerable to MS（OR=1.190,1.547,2.243）. Conclusions MCHC is closely correlated with MS and its components,and it can beused as a predictor of MS.