甲状腺未分化癌:16例超声特点分析并文献复习

Anapl astic thyroid carcinoma: analysis of ultrasonic features of 16 cases and review literature

目的探讨甲状腺未分化癌的超声特点。方法选择中国医科大学附属盛京医院2008年至2014年诊治的16例甲状腺未分化癌患者,其中男性5例,女性11例;年龄34~77岁,平均年龄60.8岁。回顾性分析其超声特点,并总结近10年来国内外发表的甲状腺未分化癌的超声特点。以甲状腺未分化癌、超声、thyroid anaplastic carcinoma、ultrasound为主题词,检索中国知网（CNKI）、万方数据库、中国生物医学文献光盘数据库、维普数据库、Cochrane图书馆和Pub Med数据库。结果 16例甲状腺未分化癌肿物最大径为1.6~6.7 cm,统计值（4.21±1.84）cm。16例及既往已发表7篇文献55例甲状腺未分化癌多见于60岁左右女性患者,肿物多较大,超声特点多表现为形态不规整的实性低回声,内部血流信号丰富,可伴有大小不等的钙化、甲状腺周围组织的侵犯及颈部淋巴结肿大。结论甲状腺未分化癌具有一定的超声特点,超声有助于其诊断。

Objective To evaluate the ultrasonic features of anaplastic thyroid carcinoma（ATC）. Methods From 2008 to 2014, a total of 16 patients with ATC were enrolled, which included 5 males and 11 females, aged 34 - 77 years old with mean age of 60.8 years old. The ultrasound features were retrospective analyzed, and ATC ultrasound features of published literature at past l0 years were summarized. The thyroid anaplastic carcinoma, and ultrasound in Chinese and English were set as the key- words for searching at CNKI, Wanfang data, Chinese Biomedical Literature database, VIP database, Cochrane Library and PubMed database. Results The largest diameter of 16 cases ATC was 1.6 - 6.7 cm（statistics of 4.21 cm ＋ 1.84 cm）. The ul- trasound features of ATC in 16 cases and 55 cases of 7 published literature were common showed female patient about 60- year-old. The tumors were large relatively; ultrasound features showed solid hypoechoie with irregular shape, the blood flow signals were rich, which combined with varied calcification, invasion surrounding thyroid tissue and cervical lymph nodes. Conclusion It is demonstrated that ATC have some ultrasound characteristics, so ultrasound could help diagnose of ATC.