不同血液透析膜材料在重症胰腺炎治疗中的生物相容性分析

Biocompatibility of different hemodialysis membrane materials in the treatment of severe acute pancreatitis

背景:对重症胰腺炎进行血液透析治疗时,可选用不同的透析膜材料,不同透析膜材料生物相容性是否存在差异?目的:对比聚砜膜和醋酸纤维素膜透析膜材料的生物相容性。方法:纳入100例重症胰腺炎患者,其中男51例,女49例,年龄34-81岁,均接受血液透析治疗,其中50例采用聚砜膜,另50例采用醋酸纤维素膜,透析5 h/次,3次/周。透析3个月后,比较两组透析后的腹痛与腹胀有效缓解时间、血淀粉酶水平恢复至正常水平的时间、治疗有效率及炎性因子水平的变化。结果与结论:聚砜膜组与醋酸纤维素膜组血淀粉酶水平恢复至正常水平的时间、腹痛及腹胀有效缓解时间、治疗有效率比较差异无显著性意义。两组透析后的白细胞介素6、C-反应蛋白、肿瘤坏死因子α水平均显著低于透析前(P<0.05),但两组之间比较差异均无显著性意义。结果表明对重症胰腺炎患者进行血液透析治疗时,使用聚砜膜和醋酸纤维素膜两种膜材料均具有良好的生物相容性。

BACKGROUND：In the clinical treatment of severe acute pancreatitis, there are different dialysis membrane materials. But the differences among these dialysis membrane materials are unclear. OBJECTIVE：To compare the biocompatibility of polysulfone and cel ulose acetate dialysis membranes. METHODS：Total y 100 severe acute pancreatitis patients were included, including 51 males and 49 females, aged 34 to 81 years, and al were subjected to hemodialysis treatment （5 hours once, three times per week）. Polysulfone membrane was used in 50 cases, and cel ulose acetate dialysis membrane used in the other 50 cases. After 3 months of fol ow-up, the time of recovery from abdominal pain and abdominal distension, the time of blood amylase returning to normal levels, therapeutic efficacy and level of inflammatory factors were compared between two groups. RESULTS AND CONCLUSION：There were no differences in the time of recovery from abdominal pain and abdominal distension, the time of blood amylase returning to normal levels, and therapeutic efficacy between the two groups. The levels of interleukin-6, C-reactive protein and tumor necrosis factor alpha in the two groups were significantly lower than those before hemodialysis treatment （P〈0.05）, but there was no significant difference between the two groups. Results show that both polysulfone and cel ulose acetate membranes used in hemodialysis treatment of severe acute pancreatitis have good biocompatibility.