乙肝相关肝癌患者肝组织硬脂酰-辅酶A脱氢酶的表达与预后的相关性

The relationship between the expression of stearoyl-CoA desaturase in liver tissue and the prognosis of HBVrelated hepatocellular carcinoma patients

目的:探讨乙肝相关肝癌组织中硬脂酰-辅酶A脱氢酶(stearoyl-CoA desaturase,SCD)的表达水平及临床意义。方法:构建176例距离肝癌边界3cm以上肝组织的组织芯片,应用免疫组化技术检测SCD的表达水平,并分析其与临床病理学特征之间的关系。结果:SCD在乙肝相关肝癌患者肝组织中的阳性率为85.80%(151/176)。且肝组织中SCD表达量与肿瘤数目、微血管侵犯、肝硬化等相关(P<0.05),SCD高水平表达组患者无瘤生存时间和总体生存时间均短于SCD低水平表达组。结论:SCD在乙肝相关肝癌患者肝组织中的表达量与临床病理及不良预后之间存在一定联系,提示肝癌患者肝组织中SCD的表达量可以作为不良预后的标志物。

Objective：To investigate the expression level and clinical significance of stearoyl-CoA desaturase（SCD）in liver tissues of HBV-related hepatocellular carcinoma（HCC）patients.Methods：We constructed the tissue microarray of liver tissue 3cm beyond the HCC boundary（n=176）,detected the expression level of SCD by immunohistochemistry,and analyzed the relationship between the expression level and clinical pathological features.Results：The positive rate of SCD in liver tissues of patients with HBV-related HCC patients was 85.80%（151/176）.The SCD expression level was associated with tumor number,microvascular invasion,liver cirrhosis（P〈0.05）.The tumor free survival time and overall survival time of SCD high level expression group were both shorter than those of SCD low level expression group.Conclusions：The SCD expression level in the liver tissues of HBV-related HCC patients is related to clinical pathology and prognosis,which suggests that the expression of SCD in the liver tissues of HCC patients can be used as a marker of poor prognosis.