达泊西汀联合喹硫平治疗男性早泄的临床观察

Observation on the clinical efficacy of Dapoxetine combined with Quetiapine in treating Premature Ejaculation

目的观察达泊西汀联合喹硫平治疗男性早泄的临床疗效。方法选取本院164例男性早泄患者,使用随机数字表法分为对照组和观察组,每组各82例,单用达泊西汀为对照组,联合使用达泊西汀与喹硫平为观察组。比较两组治疗前后的CIPE评分,5-HT浓度,IELT数值。结果经治疗后,两组的CIPE评分、5-HT浓度、IELT数值与治疗前比较,均有改善,具有统计学意义(P<0.05)。其中,观察组改善幅度更大,两组间比较,观察组CIPE评分、5-HT浓度、IELT数值上的改善也明显优于对照组,差异具有统计学意义(P<0.05)。结论达泊西汀联合喹硫平治疗男性早泄的疗效更为显著,有效率更高。

Objective To observe the clinical efficacy of the combination of Dapoxetine and Quetiapine in the treatment of Premature Ejaculation（ PE）. Methods 164 patients with Premature Ejaculation were randomly divided into observation group and control group. The control group was treated by Dapoxetine. The observation group was treated by Dapoxetine and Quetiapine. The concentration of CIPE,IELT and 5- HT were assessed before and after the treatment.Results After treatment,the score of CIPE,number of IELT and 5-HT concentration were improved in both observation group and control group. However, the improvement in observation was more significant,including the score of CIPE,number of IELT and 5- HT concentration（ P〈0.05）. Conclusions The combination of Dapoxetine and Quetiapine has significant clinical efficacy in the treatment of Premature Ejaculation.