噻吗洛尔和卡替洛尔外用治疗婴幼儿血管瘤疗效观察

Topical timolol versus carteolol for the treatment of infantile hemangiomas： a clinical observation

目的 评价和比较噻吗洛尔和卡替洛尔溶液外用治疗婴幼儿浅表型血管瘤的疗效.方法 163例婴幼儿浅表型血管瘤,分为噻吗洛尔组和卡替洛尔组,用0.5％马来酸噻吗洛尔滴眼液或2％盐酸卡替洛尔滴眼液滴于纱布湿敷于瘤体,每天2次,每次30分钟,治疗4个月,观察疗效及不良反应.结果 噻吗洛尔组82例,平均瘤体厚度从治疗前（2.51±1.36）mm减至（1.54±1.55）mm,疗前后比较P＜0.01.卡替洛尔组81例,瘤体厚度从（2.45±1.37）mm减至（2.00±1.41）mm,疗前后比较P＜0.05.噻吗洛尔组治疗有效率81.71％,显著高于卡替洛尔组的46.91％,两组比较P＜0.01.两组增生期瘤体治疗有效率均高于消退期（P＜0.05）.结论 噻吗洛尔溶液湿敷治疗婴幼儿浅表型血管瘤方便且效果确切,增生期瘤体效果更佳.

Objective To evaluate and compare the efficacy of topical timolol solution versus carteolol solution for the treatment of superficial infantile hemangiomas.Methods Totally,163 infants with superficial infantile hemangiomas were divided into 2 groups to be topically treated with timolol maleate 0.5% eye drops （n =82,timolol group） and carteolol hydrochloride 2% eye drops （n =81,carteolol group） respectively for 30 minutes twice a day for 4 consecutive months.Both the eye drops were firstly dropped to six pieces of gauze,then the wet gauze was used to cover hemangiomas for treatment.At the end of treatment,efficacy and adverse reactions were observed.Results The thickness of hemangiomas decreased significantly from 2.51 ± 1.36 mm before the treatment to 1.54 ± 1.55 mm after the treatment in the timolol group （P 〈 0.01）,and from 2.45 ± 1.37 mm before the treatment to 2.00 ± 1.41 mm after the treatment in the carteolol group （P 〈 0.05）.The response rate was significantly higher in the timolol group than in the carteolol group （81.71% [67/82]vs.46.91% [38/81],P 〈 0.01）.In addition,hemangiomas in proliferative phase showed a significantly higher response rate compared with those in stable phase in both groups （both P 〈 0.05）.Conclusion Wet compress with timolol solution is effective and convenient for the treatment of superficial infantile hemangiomas,especially for those in proliferative phase.