皮肤假性淋巴瘤的研究进展

Cutaneous pseudolymphoma

皮肤假性淋巴瘤系指临床表现或组织病理类似恶性淋巴瘤,但又不满足恶性淋巴瘤诊断标准的一组淋巴细胞增生性病变.根据皮损中浸润淋巴细胞的主要类型,可分为皮肤B细胞假性淋巴瘤和皮肤T细胞假性淋巴瘤.临床表现多样,通常为红色斑块、丘疹或结节,头颈部多见.部分皮损有自愈性和复发性.组织学上可见淋巴细胞浸润,一般呈多克隆增生,但易与其他恶性疾病混淆.皮肤假性淋巴瘤尚无特效治疗方法,目前的治疗包括手术切除、光动力疗法、干扰素等,但可能复发.本病预后良好,但有转变为恶性淋巴瘤的可能,需要长期随访.

Cutaneous pseudolymphoma （CPL） refers to a group of lymphoproliferative diseases which are similar to cutaneous malignant lymphoma （CML） in terms of clinical manifestations and histopathological features,but does not meet the diagnostic criteria for CML.According to the main types of lymphocytes infiltrating the lesions,CPL is divided into cutaneous B-cell pseudolymphoma and cutaneous T-cell pseudolymphoma.CPL has various clinical manifestations,usually including red plaques,papules and nodules mostly in the head and neck.Some lesions appear to heal spontaneously and recur.Histologically,there may be infiltration of polyclonal proliferative lymphocytes,so it is easily mistaken for other malignant diseases.There are no specific treatments for CPL.Present therapeutic approaches include surgical excision,photodynamic therapy,interferon,etc,but recurrence may occur.Despite of a relatively good prognosis,CPL can progress to CML,so a long-term follow-up is indispensable.