脑梗死后认知障碍与血清视锥蛋白样蛋白-1水平及神经功能缺损关系的研究

Relationship of cognitive impairment after cerebral infarction with serum level of visinin-like protein-1 and neural functional deficiency

目的探讨脑梗死后认知障碍与血清视锥蛋白样蛋白-1(VILIP-1)水平及神经功能缺损的相关性。方法收集120例急性脑梗死患者,根据蒙特利尔认知评估量表(Mo CA)测评结果分为认知障碍组和认知正常组,比较两组患者入院时和发病1年时血清VILIP-1水平、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分,分析Mo CA分值与血清VILIP-1水平、NIHSS评分和BI评分的相关性。结果两组患者发病1年时NIHSS评分均低于入院时(P<0.01);BI评分均高于入院时(P<0.01)。认知障碍组入院时及发病1年时血清VILIP-1水平高于认知正常组(P<0.01);NIHSS评分高于认知正常组(P<0.01);BI评分低于认知正常组(P<0.01)。入院时及发病1年时所有患者Mo CA分值与血清VILIP-1水平呈负相关(r=-0.736,P=0.000;r=-0.450,P=0.000);与NIHSS评分呈负相关(r=-0.575,P=0.000;r=-0.377,P=0.001);与BI评分呈正相关(r=0.431,P=0.000;r=0.483,P=0.000)。结论脑梗死后认知障碍与血清VILIP-1水平及神经功能的康复有重要相关性。

Objective To investigate the relationship of cognitive impairment after cerebral infarction with serum level of visinin-like protein-1 （ VILIP-1 ） and neural functional deficiency. Methods One hundred and twenty patients with acute cerebral infarction were enrolled and divided into impaired cognition group and normal cognition group according to their Montreal Cognitive Assessment （ Mo- CA） performance. Serum level of VILIP-1, National Institutes of Health Stroke Scale （NIHSS） score, and Barthel index （BI） score on admission and at 1 year after stroke were compared between the two groups. The relationship of MoCA score with serum level of VIL- IP-1, NIHSS score, and BI score was analyzed. Results Patients in the two groups had significantly lower NIHSS scores and significantly higher BI scores at 1 year after stroke than on admission （ both P 〈 0.01 ）. The impaired cognition group had a significantly higher serum level of VILIP-1, a significantly higher NIHSS score, and a significantly lower BI score than the normal cognition group on admission and 1 year after stroke （all P 〈 0.01 ）. The MoCA score was negatively correlated with the serum VILIP-1 level and the NIHSS score, and positively correlated with the BI score on admission （ r = - 0. 736, P = 0.000 ; r = - 0.575, P = 0.000 ; r = 0. 431, P = 0. 000） and at 1 year after stroke （ r = - 0.450, P = 0. 000 ; r = - 0. 377, P = 0. 001 ; r = 0.483, P = 0.000）. Conclusions Cognitive impairment after cerebral infarction has important impacts on the serum level of VILIP-1 and neural function recovery.