摘要
目的探讨TPFI-2、VEGF在EBUS-TBNA获取非小细胞肺癌患者转移淋巴结中的表达及相关性。方法运用EBUS-TBNA技术获取非小细胞肺癌患者纵隔、肺门转移淋巴结组织标本40例及非转移肿大淋巴结组织标本10例,通过免疫组化检测其中的TFPI-2、VEGF表达,同时测定MVD,进行相关因素分析。结果非小细胞肺癌转移淋巴结中:(1)TFPI-2、VEGF的表达水平与患者吸烟指数、肺癌临床分期、是否有淋巴结转移有关(P<0.05);(2)TFPI-2与VEGF表达呈负相关(P<0.05);(3)高、低MVD组中的TFPI-2、VEGF阳性表达率存在明显差异(P<0.05)。结论非小细胞肺癌转移淋巴结中TFPI-2、VEGF的表达与吸烟、TNM分期、淋巴结转移、MVD有关,且TFPI-2可能通过下调VEGF表达来抑制非小细胞肺癌肿瘤新生血管的形成。
Objective To explore the expression and clinical significance of TPFI-2 and VEGF in metastatic lymph nodes of Non-small cell lung cancer by EBUS-TBNA. Methods Obtained 40 specimen of mediastinal lymph nodes and hilar lymph node and 10 specimen of non-MLPN of Nonsmall cell lung cancer by EBUS-TBNA. Detected the TPFI-2, VEGF and MVD by immunohis-to-chemistry examine and taken correlation factor analysis. Results In metastatic lymph nodes of Non-small cell lung cancer:(1) The expression level of TPFI-2 and VEGF was related to smoking index, clinical staging of lung cancer and lymph node metastasis(P〈0.05).(2) Significant negative correlation was found between TPFI-2 and VEGF(P〈0.05).(3) There was significant difference of positive rate of TPFI-2 and VEGF between high MVD group and low MVD group(P〈0.05). Conclusion The expression level of TPFI-2 and VEGF in metastatic lymph nodes of Non-small cell lung cancer was related to smoking index, clinical staging, lymph node metastasis and MVD. TPFI-2 can inhibit the start of neovascularization in non-small cell lung cancer by the decrease of VEGF.
出处
《中国继续医学教育》
2016年第33期69-70,共2页
China Continuing Medical Education