血清尿酸(SUA)水平对缺血性心力衰竭(HF)患者心房颤动(AF)发生的影响研究

The effect of serum uric acid(SUA)on atrial fibrillation(AF)in patients with ischemic heart failure(HF)

目的：探究血清尿酸（SUA）水平对缺血性心力衰竭（HF）患者心房颤动（AF）发生的影响。方法：选取2011年1月-2015年8月于我院接受治疗的缺血性心力衰竭患者，152例，根据病历，将伴有心房颤动的患者纳入观察组，将无心房颤动患者纳入对照组，其中，观察组41例，对照组111例。比较两组多种单因素与缺血性心力衰竭患者心房颤动的相关性以及有统计学意义的相关因素行多因素Logistic回归分析。结果：观察组平均年龄（71±9）岁，明显高于对照组平均年龄（65±11）岁，差异明显，具有统计学意义（P〈0．05）。而两组在性别、吸烟情况、并发症方面，差异不明显（P〉0．05）。观察组LVEF值为（33±6）％，明显低于对照组的（36＋6）％，差异明显，具有统计学意义（P〈0．05）；观察组LAD、LVEDD、LVEDV明显高于对照组，差异明显，具有统计学意义（P〈0．05）。观察组血清尿酸（SUA）含量为（382±125）mmol／L，明显高于对照组的（338＋112）mmol／L，差异明显，具有统计学意义（P〈0．05）。两组空腹血糖值、血清肌酐、总胆固醇、血白细胞、三酯甘油、低密度脂蛋白胆固醇（LDL-C）、尿素氮含量经统计学检验无显著差异（P〉0．05）。经logistic回归方程检验，年龄的OR系数为3．522，LAD的OR系数为1．050，SUA的OR系数为1．442，在多因素分析中年龄的高低、LAD的大小、SUA含量的多少与观察组缺血性心力衰竭伴有心房颤动病情显著独立相关（P〈0．05）。结论：血清尿酸水平是缺血性心力衰竭患者心房颤动发生的独立显著相关因素。

Objective：To explore the effect of serum uric acid （SUA） level on atrial fibrillation （AF） in patients with ischemic heart failure （HF）. Method： 152 patients with ischemic heart failure treated in our hospital were selected as the study subjects from January 2011 to August 2015. According to the patient＇s personal history, patients with atrial fibrillation were included in the observation group, patients without atrial fibrillation were included in the control group.Among them, Observation group had 41 cases, Control group had 111 cases.The correlation of multiple single factor and atrial fibrillation in patients with ischemic heart failure, as well as, multivariate Logistic regression analysis of correlative factors with statistical significance were compared between the two groups. Result：The patients in the observation group were （71±9） years old, significantly higher than the control group of patients with age, the control group of patients is （65±11 ） years old, obviously difference, with statistical significance （P〈O.05）. And the two groups of patients in gender, smoking, complications, the difference was not obvious （P〉0.05）.The LVEF index of the observation group was （33±6）%, significantly lower than the control group, the control group of the LVEF index is （36 ± 6）%, obviously difference, with statistical significance （P〈 0.05 ）;The observation group LAD, LVEDD, LVEDV was significantly higher than the control group, the difference was obvious, with statistical significance （P〈0.05）.The serum uric acid （SUA） content in the observation group was （382±125） mmol/L, obviously higher than the control group, the control group of serum uric acid SUA content is （338±112） mmol/L, obviously difference, with statistical significance （P〈0.05）.Fasting blood glucose, serum creatinine, total cholesterol, blood white blood cell, three ester of glycerol, low density lipoprotein cholesterol （LDL-C） and urea nitrogen in the two groups were not significantly different （P〉0.05）.By logistic regression equation test,the age of the OR coefficient was 3.522,the OR coefficient of LAD is 1.05,the OR coefficient of SUA is 1.442, In the multi factor analysis, the age of the high and low, the size of LAD, the number of SUA content and the observation group were significantly independent （P〈0.05）. Conclusion The serum uric acid level was an independent and significant correlation factor of atrial fibrillation in patients with ischemic heart failure.