摘要
目的:探讨不同类型急性白血病Cox-2蛋白的表达与临床特征的关系。方法:应用流式细胞仪定量检测本院2013年6月~2016年6月住院治疗的30例急性白血病患者与8例正常人骨髓Cox-2的表达水平,并探讨急性白血病的表达与诊断分型的关系。结果:正常对照组Cox-2阳性率12.5%,急性淋巴细胞白血病Cox-2阳性率11.1%,急性髓系白血病Cox-2阳性率52.4%,组间比较有显著差异(P〈0.05)。急性髓系白血病中,不同亚型的Cox-2荧光指数分别M1(1.41±0.31),M2(1.83±0.58);M3(1.67±0.45);M4(2.72±0.71);M5(2.83±0.96);组间差异有统计学意义(P〈O.05),M4,M5亚型Cox-2荧光指数较其他组明显升高。结论:急性髓系白血病特别是M4、M5亚型Cox-2蛋白表达升高,提示Cox-2高表达可能与急性髓系白血病的发生发展有关。
Objeetiv:To investigate the relationship between the expression of Cox-2 protein and the clinical characteristics in different types of acute leukemia. Methods:the expression levels of Cox-2 from nanhai hospital between 2013/6 and 2016/6 in 30 cases of acute leukemia and 8 normal persons were detected by flow cytometry, and the relationship between the expression of acute leukemia and the diagnosis of acute leukemia was also discussed. Results:the positive rate of Cox-2 in normal control group was 12.5%, the positive rate of Cox-2 in acute lymphoblastie leukemia was 11.1%, the positive rate of Cox-2 in acute myeloid leukemia was 52.4%, there was significant difference between the two groups (P〈0.05). Acute myeloid leukemia, fluorescence index of different subtypes of COX-2 were MI (1.41±0.31), M2 (1.83±0.58), m3 (1.67±0.45), M4 (2.72±0.71), M5 (2.83±0.96). The difference between the two groups have statistical significance (P〈0.05), M4, M5 subtype COX-2 fluorescence index than the other groups increased signific, antly. Conclusion:in the acute myeloid leukemia, especially M4, the expression of M5 protein is increased, which suggests that the high expression of Cox-2 may be related to the occurrence and development of acute myeloid leukemia. Key words:Cox-2 flow eytometry acute leukemia
出处
《北方药学》
2016年第12期130-131,共2页
Journal of North Pharmacy
基金
佛山市医学类科技攻关项目资助项目(编号:2014AB000192)