大血管狭窄与脑白质疏松患者认知功能损害的相关性研究

The Relationship Between Cognitive Impairment in Patients With Vascular Stenosis and Cerebral White Matter

目的探讨大血管狭窄与脑白质疏松患者认知功能损害的相关性。方法选取在我院进行治疗的脑白质疏松患者74例,按是否存在认知功能损害分为两组,认知功能正常为对照组(34例),有皮质下血管性认知功能障碍为观察组(40例),比较两组简易智能精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)及剑桥老年认知功能评估量表-中文版(CAMCOG-C)评分及血管狭窄程度。结果观察组MMSE、MoCA、CAMCOG-C评分均低于对照组,差异均具有统计学意义(P<0.05);观察组大血管狭窄上升程度高于对照组,差异具有统计学意义(P<0.05)。结论随着大血管狭窄程度越严重,脑白质疏松患者认知功能损伤越严重。

Objective To investigate the relationship between the cognitive impairment in patients with large vascular stenosis and the patients with cerebral white matter. Methods 74 cases of patients with leukoaraiosis patients treated in our hospital, according to the cognitive function impairment were divided into two groups, normal cognitive function as the control group （34 cases）, with subcortical vascular cognitive impairment as the observation group （40 cases）, compared two groups of Mini Mental State Scale （MMSE）, Montreal cognitive Assessment Scale （MoCA） and Cambridge cognitive assessment scale - Chinese Version （CAMCOG-C） score and the degree of vascular stenosis. Results Compared with the control group, the MMSE, MoCA and CAMCOG-C scores in the observation group were signiifcantly lower than those in control group （P〈 0.05）. The degree of stenosis of the observation group was signiifcantly higher than that of control group （P 〈 0.05）.Conclusion More serious the degree of vascular stenosis, the more severe cognitive impairment in patients with white matter.