沙利度胺联合TP方案治疗晚期非小细胞肺癌临床研究

Clinical Study on Thalidomide Combined With TP Scheme in the Treatment of Advanced Non-small Cell Lung Cancer

目的探究沙利度胺联合TP方案治疗晚期非小细胞肺癌临床效果。方法选取我院60例晚期非小细胞肺癌患者,随机数表法分组,每组各30例。对照组仅给予TP方案治疗,观察组给予TP方案联合沙利度胺治疗,两组均治疗4个周期。统计对比两组治疗效果、生活质量。结果两组治疗有效率比较,差异无统计学意义(P>0.05);观察组病情控制率为86.67%,对照组病情控制率为50.00%,差异具有统计学意义(P<0.05);观察组生活质量评分高于对照组,差异具有统计学意义(P<0.05)。结论沙利度胺联合TP方案治疗晚期非小细胞肺癌能有效提高患者疾病控制率、生活质量。

Objective To explore the effcacy of thalidomide combined with TP regimen in the treatment of advanced non-small cell lung cancer clinical effect.Methods60 patients with advanced non-small cell lung cancer were selected in our hospital, the random number table method, 30 cases in each group. The control group was given only TP regimen, the observation group was given TP combined with thalidomide treatment, two groups were treated for 4 cycles. Statistical comparison of two groups of treatment effect, quality of life.ResultsThe effective rate of treatment was compared between the two groups, the difference was not statistically signiifcant （P〉 0.05）. The control rate of observation group was 86.67%, the control rate of the control group was 50.00%, the difference was statistically signiifcant （P〈 0.05）. The quality of life in the observation group was higher than that in the control group, the difference was statistically signiifcant （P 〈 0.05）. Conclusion Thalidomide combined with TP regimen in the treatment of advanced non-small cell lung cancer patients can effectively improve the disease control rate, quality of life.